功能性胰腺神经内分泌肿瘤的药物治疗进展

Advances in medical treatment of functional pancreatic neuroendocrine tumor

胰腺神经内分泌肿瘤(pancreatic neuroendocrine tumor,pNET)可来源于多种神经内分泌细胞,不同类型其临床表现、进展与预后各有不同。针对其中能够产生过量激素的功能性pNET,治疗时需兼顾抑制肿瘤生长与激素分泌。除了传统的手术治疗与化疗,近年来在生长抑素类似物(somatostatin analogue,SSA)、靶向药物、免疫检查点抑制剂、肽受体放射性核素疗法以及多种疗法联合使用方面取得了新的进展,为不同肿瘤类型和分期的患者提供了更多干预手段。本文对近年来功能性pNET的治疗进展进行综述,并对不同激素类型的pNET的药物治疗进行逐一总结。

Pancreatic neuroendocrine tumor(pNET)originates from various neuroendocrine cells,which contributes to different clinical manifestations,progress and prognosis.Functional pNET produces excessive hormones,and thus tumor growth inhibition and hormone control should be both taken into consideration during intervention.In addition to the traditional surgical treatment and chemotherapy,a rapid development was showed in recent years in medical treatments like somatostatin analogue(SSA),targeted agents,immune checkpoint inhibitors,peptide receptor radionuclide therapy and so on,providing more intervention tools for patients with different tumor types and stages.This article intends to review advance in medical treatments of functional pNET and summarize the drug therapy of pNET with different hormone types.