阿奇霉素在急性中耳炎患儿抗感染治疗中的应用价值

The Application Value of Azithromycin in Anti Infection Treatment of Children with Acute Otitis Media

目的探讨阿奇霉素在急性中耳炎患儿抗感染治疗中的应用价值。方法选取2018年3月至2019年3月寻乌县人民医院耳鼻喉科收治的70例急性中耳炎患儿作为研究对象,按照随机数字表法分为对照组与观察组,各35例。对照组给予阿莫西林克拉维酸钾分散片治疗,观察组患者给予阿奇霉素分散片治疗。比较两组治疗效果、治疗前后阳性体征发生情况及不良反应发生率。结果观察组治疗有效率高于对照组(97.14%比82.86%),差异有统计学意义(χ~2=2.540,P=0.046);两组治疗前后临床阳性体征(耳痛、烦躁、眩晕听力减退及骨膜异常)发生率比较,差异无统计学意义(P>0.05);治疗后,两组阳性体征发生率明显低于治疗前,差异有统计学意义(P<0.05);观察组不良反应发生率略低于对照组(14.29%比20.00%),但差异无统计学意义(χ~2=0.402,P=0.526)。结论急性中耳炎患者给予阿奇霉素抗感染治疗,能够显著提高治疗效果,可在一定程度上减少耳痛、听力下降、骨膜异常等阳性体征发生,且不良反应相对较少,安全性较好。

Objective To explore the application value of azithromycin in anti-infection treatment of child patients with acute otitis media. Methods A total of 70 children with acute otitis media admitted to Otolaryngology Department of Xunwu County People’s Hospital from March 2018 to March 2019 were selected as the study subjects. They were divided into control group(n=35 cases) and observation group(n=35 cases) according to random number table method. The control group was treated with amoxicillin and clavulanate potassium dispersible tablets, while the observation group was treated with Azithromycin Dispersible tablets. The therapeutic effects, occurrence rates of positive signs and incidence rates of adverse reactions before and after treatment were compared between the 2 groups. Results The total effective rate of the observation group was higher than that of the control group(97.14% VS 82.86%), with significant difference(χ2=2.540, P=0.046);There was no significant difference in the incidence of clinical positive signs(earache, irritability, vertigo, hearing loss and periosteal abnormality) between the 2 groups before and after treatment(P>0.05).After treatment, the incidence of adverse signs in the 2 groups was significantly lower than before treatment(P<0.05);the incidence of adverse signs in the observation group was slightly lower than that in the control group(14.29% VS 20.00%), but there was no significant difference(χ2=0.402, P=0.526). Conclusion Azithromycin anti-infective therapy used in patients with acute otitis media can significantly improve the therapeutic effects, reduce the occurrence of signs such as earache, hearing loss and periosteal abnormalityetc. to a certain extent, and has relatively few adverse reactions and better safety.