前列地尔联合阿司匹林治疗老年心绞痛冠状动脉慢血流的疗效及对血管内皮功能的影响

Effect of Alprostadil Combined with Aspirin on Vascular Endothelial Function in Coronary Slow Blood flow in Elderly Patients with Angina Pectoris

目的:探讨前列地尔联合阿司匹林治疗老年心绞痛冠状动脉慢血流的疗效及对血管内皮功能的影响。方法:选择2015年1月至2018年10月我院接诊的115例冠状动脉慢血流型心绞痛患者,通过随机数表法分为观察组60例和对照组55例,在常规治疗基础上,对照组给予阿司匹林治疗,观察组联合前列地尔治疗,均连续治疗3个月。比较两组临床疗效、血管内皮功能、心绞痛发作情况、矫正心肌梗死溶栓试验(TMIT)血流帧数的变化及安全性。结果:治疗后,观察组临床疗效总有效率明显高于对照组(P<0.05);两组血清一氧化氮(NO)、内皮素-1(ET-1)、内皮依赖性血管舒张功能(FMD)、心绞痛每日发作次数及持续时间、矫正TMIT血流帧数在组间、不同时间点比较,差异有统计学意义(P<0.05),且均具有交互作用(P<0.05);两组不良反应总发生率差异无统计学意义(P>0.05)。结论:前列地尔联合阿司匹林治疗老年冠状动脉慢血流型心绞痛效果显著,可有效改善血管内皮功能,促进冠状动脉血流恢复,缓解临床症状,临床应用价值高。

Objective: To study the effect of alprostadil combined with aspirin on vascular endothelial function in coronary slow blood flow in elderly patients with angina pectoris. Methods: 115 patients with coronary slow flow angina admitted to our hospital from January 2015 to October 2018 were randomly divided into observation group(60 cases) and control group(55 cases). On the basis of routine treatment, the control group was given aspirin treatment, and observation group was treated with Alprostadil for 3 consecutive months. The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). No, ET-1, FMD, the number and duration of angina pectoris attack per day, the number of corrected tmit blood flow frames were statistically significant(P>0.05). Results: After treatment, the total effective rate in the observation group was significantly higher than that of the control group(P<0.05). There were significant differences in serum nitric oxide(NO), endothelin-1(ET-1), Endothelial Dependent Vasodilation Function(FMD), the number and duration of angina pectoris daily attacks and Corrected TMIT Blood Flow Frames between the two groups at interblock, different time points(P<0.05), and they all have interaction(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion: Alprostadil combined with aspirin has a significant effect in the treatment of elderly patients with coronary slow flow angina, which can effectively improve the endothelial function, promote the recovery of coronary blood flow, relieve clinical symptoms, and has a high clinical application value.