300例自发性慢性荨麻疹患者过敏原检测分析

Analysis of Allergen Detection in 300 Patients with Spontaneous Chronic Urticaria

目的:检测自发性慢性荨麻疹(Chronic urticaria,CU)患者血清中特异性IgE(Specific IgE,sIgE)抗体,为该病的预防提供依据。方法:采用德国进口Medwiss敏筛过敏原检测系统对300例自发性CU患者血清sIgE进行测定。 结果:300例自发性CU患者sIgE阳性者193例,阳性率为64.3 %。吸入性过敏原前三位分别是尘螨、草组合、霉菌组合;食物性过敏原前三位分别是腰果、苋菜、牛奶。男性组和女性组比较,两组总的sIgE检出率及吸入性sIgE和食物性sIgE检出率差异均无统计学意义 ( p>0.05)。儿童组和成人组比较,两组总的sIgE检出率及吸入性sIgE检出率无差异,而儿童组中食物性sIgE检出率高于成人组。结论:自发性CU的发生与sIgE有关,过敏原检测有助于自发性CU患者的治疗和预防。

Objective: Specific IgE(sIgE) in serum of patients with Chronic urticaria(CU) were detected to provide basis for the prevention of the disease. Methods: The serum sIgE of 300 cases with spontaneous chronic urticaria were detected by Medwiss allergen detection system imported from Germany. Results: Among the 300 patients, 193 cases were positive for sIgE,with a positive rate of 64.3%. The top three inhaled allergens were dust mite, grass combination, mold combination. The top three food allergens were cashew nuts, amaranth, milk.Compared with the male group and the female group, there was no difference in the total sIgE detection rate and the sIgE detection rate of inhalation and food(P>0.05). There was no difference between the total sIgE detection rate and the inhalation sIgE detection rate between the children group and adults group(P>0.05),while the food sIgE detection rate of children group was higher than that of the adult group(P<0.05). Conclusion: The occurrence of spontaneous CU is related to serum sIgE, allergen detection is helpful for the treatment and prevention of patients with spontaneous chronic urticaria.