长链非编码RNA及相关调控通路与急性心肌梗死的研究进展

Long Non-coding RNA and Its Related Regulatory Pathways and Acute Myocardial Infarction

急性心肌梗死是指冠状动脉血供急剧减少或中断,使相应心肌严重而持久的缺血坏死。长链非编码RNA(lncRNA)是指一类长度超过200 nt的非编码RNA。研究证明多种lncRNA及其相关靶调控通路参与急性心肌梗死的发生和发展。现阐述lncRNA及相关调控通路与急性心肌梗死的研究现状,探讨lncRNA及其相关调控通路作为急性心肌梗死诊断的精准生物标志物及治疗、改善预后的潜在靶点的可能性及面临的挑战。

Acute myocardial infarction(AMI)refers to the severe and persistent ischemic necrosis of the corresponding myocardium caused by the sharp decrease or interruption of coronary blood supply.Long non-coding RNA(lncRNA)refers to a class of non-coding RNA whose length exceeds 200 nt.It has been proved that a variety of lncRNA and its related target regulatory pathways are involved in the occurrence and development of AMI.The aim of this article is to elucidate the research status of lncRNAs expression and related regulatory pathways in acute myocardial infarction,and to explore the possibility and challenges of using lncRNA and its related regulatory pathways as precise biomarkers for the diagnosis and treatment of AMI and potential targets for improving prognosis.