脓毒症型心肌病的研究进展

Septic Cardiomyopathy

脓毒血症致心肌抑制又称为脓毒症型心肌病。18%~65%的脓毒症患者会出现心肌抑制,死亡率为40%~70%,发病7~19 d后心功能可能恢复,其病因、发病机制不明,治疗也无特异性。脓毒症引起的复杂的心肌炎症反应和线粒体非稳态,最终导致心肌功能不全。脓毒症致心肌抑制成为影响脓毒症预后的重要因素。现就脓毒症型心肌病的发病机制、临床诊断和治疗进展做一总结。

Septic cardiomyopathy is known as sepsis-induced myocardial depression.18%~65%septic patients suffered from myocardial depression and its mortality rate is 40%~70%.Heart function may recover in 7~19 days after the onset of sepsis.The etiology,pathogenesis and treatment of septic cardiomyopathy are uncertain except that sepsis leads to a complex intramyocardial inflammatory response and mitochondrial non-homeostasis,which may result in myocardial dysfunction.Since sepsis-induced myocardial depression is recognized as a major predictor of prognosis,the recent findings about pathogenesis,diagnosis and manipulation are reviewed in this article.