奥氮平与阿立哌唑用于老年期首发精神分裂症治疗的临床分析

Clinical Analysis of Olanzapine and Aripiprazole in the Treatment of Senile First-episode Schizophrenia

目的:分析老年期首发精神分裂症采用奥氮平与阿立哌治疗的临床效果。方法:56例老年期首发精神分裂症患者56例分为对照组与治疗组各28例,对照组应用奥氮平治疗,治疗组应用阿立哌唑治疗,对两组患者的治疗效果、不良反应发生情况进行比较。结果:两组患者的治疗总有效率差异不显著(P>0.05);两组TESS评分相比,治疗组较对照组低,存在统计学意义(P<0.05);两组治疗8周后的PANSS总分、阳性症状分、阴性症状分均比治疗前明显降低(P<0.05);且治疗组治疗2周后的阴性症状因子分低于治疗前,对照组阳性症状因子分低于治疗前(P<0.05);组间展开对比,治疗组治疗各周的阴性症状因子分均比对照组低,差异具备统计学意义(P<0.05)。结论:与奥氮平相比,阿立哌唑对老年期首发精神分裂症具有良好的治疗效果,可显著改善阴性症状,提高用药安全性。

Objective:To analyze the clinical effects of olanzapine and aripipre in the treatment of first-onset schizophrenia in the elderly.Methods:56 cases elderly patients with first-onset schizophrenia were divided into a control group(28 cases)and a treatment group(28 cases).The control group was treated with olanzapine,and the treatment group was treated with aripiprazole.The treatment effects and adverse reactions of the patients in the two groups were compared.Results:There was no significant difference in the total effective rate of treatment between the two groups of patients(P>0.05);the TESS score of patients in the treatment group was lower than that in the control group(P<0.05);the total score of PANSS and positive symptoms after 8 weeks of treatment in the two groups Scores and negative symptom scores were significantly lower than before treatment(P<0.05);and the negative symptom factor score of the treatment group after 2 weeks of treatment was lower than before treatment,and the positive symptom factor score of the control group was lower than before treatment(P<0.05);The comparison between the groups showed that the negative symptom factor scores in the treatment group were lower than those in the control group(P<0.05).Conclusion:Compared with olanzapine,aripiprazole has a good therapeutic effect on the first episode of schizophrenia in the elderly,and can significantly improve the negative symptoms and improve the safety of medication.