根管封药操作中应用糜蛋白酶注射液与Ca(OH)2的效果对比

Comparison of the clinical efficacy of Ca(OH)2 and chymotrypsin injection for root canal sealing

目的探讨Ca(OH)2与糜蛋白酶注射液用于根管封药的疗效。方法选取120例根尖周炎需行根管封药的病例开展研究,研究起止时间为2014年7月至2016年7月,按照随机数表法将120例根尖周炎病例分为2组(实验组60例,对照组60例),实验组用甲硝唑+Ca(OH)2进行根管封药,对照组用甲硝唑+蛋白酶注射液进行根管封药。对比分析临床效果。结果经采用不同根管封药治疗后,实验组总有效率为93.33%,高于对照组的80.00%(P<0.05)。实验组根管封药治疗4 d后激惹反应发生率为11.67%、重新开放处理为6.67%,均分别明显低于对照组的30.00%、21.67%(P<0.05)。治疗前两组患者的IL-4、IL-6水平比较差异无统计学意义(P>0.05);治疗后实验组IL-4(143.0±25.3)pg/ml、IL-6(165.2±46.3)pg/ml,均优于对照组,两组比较差异有统计学意义(P<0.05)。结论Ca(OH)2用于根管封药的临床疗效确切,优于糜蛋白酶注射液,具有较高应用价值。

Objective To investigate the effect of Ca(OH)2 and chymotrypsin injection in root canal sealing.Methods 120 cases of periapical periodontitis for root canal sealing from July 2014 to July 2016 were divided into 2 groups(60 cases in the experimental group,60 cases in the control group)according to the random number table method.The experimental group received root canal sealing with metronidazole+Ca(OH)2,and the control group received root canal sealing with metronidazole+chymotrypsin injection.The clinical effects of the two groups were compared and analyzed.Results After the treatment of different root canal sealing drugs,the total effective rate of the experimental group was 93.33%,higher than that of the control group(80.00%)(P<0.05).In the experimental group,the incidence of irritation reaction was 11.67%,and the reopening treatment was 6.67%after root canal therapy,which were significantly lower than those in the control group(30%and 21.67%)(P<0.05).There were no statistically significant differences in IL-4 and IL-6 levels between the two groups before treatment(P>0.05),the expression of inflammatory factors were significantly decreased in the two groups after treatment,IL-4 and IL-6 levels in the experimental group[(143.0±25.3)pg/ml,(165.2±46.3)pg/ml]were better than those in the control group,with statistically significant differences(P<0.05).Conclusion The clinical efficacy of Ca(OH)2 for root canal sealing is better than that of chymotrypsin injection,which is of high application value.