保乳术与改良根治术在早期乳腺癌治疗中的效果比较分析

Comparative analysis of the effect of breast conserving surgery and modified radical mastectomy in the treatment of early breast cancer

目的研究早期乳腺癌患者采用保乳术与改良根治术治疗的效果.方法84例早期乳腺癌患者,采用随机数字表法分为观察组与对照组,各42例.观察组采用保乳术治疗,对照组采用改良根治术治疗.比较两组手术指标、肿瘤标志物[糖类抗原153(CA153)及癌胚抗原(CEA)]、生活质量、疗效及并发症发生情况.结果术后,观察组CEA(3.81±0.42)μg/L与CA153(26.15±3.29)U/ml水平均低于对照组的(4.06±0.67)μg/L、(27.49±2.04)U/ml,差异具有统计学意义(P<0.05).观察组切口长度、手术时间、住院时间均短于对照组,术中出血量、术中引流量均少于对照组,差异均具有统计学意义(t=18.0937、15.6852、9.3692、9.2195、13.1309,P<0.05).观察组躯体能力、社会领域、情感限制及精神状态评分均高于对照组,差异均具有统计学意义(t=8.1145、31.3441、5.7555、6.6572,P<0.05).观察组有效率92.86%高于对照组的76.19%,差异具有统计学意义(χ^2=4.4594,P=0.0347<0.05).观察组并发症发生率4.76%低于对照组的19.05%,差异具有统计学意义(χ^2=4.0865,P=0.0432<0.05).结论保乳术治疗早期乳腺癌能提高整体疗效且改善血清肿瘤标志物水平,获得良好的治愈疾病效果.

Objective To study the effect of breast conserving surgery and modified radical mastectomy in the treatment of early breast cancer.Methods A total of 84 early breast cancer patients were divided into observation group and control group by random number table method,with 42 cases in each group.The observation group received breast conserving surgery for treatment,and the control group received modified radical mastectomy.The surgical indicators,tumor markers[carbohydrate antigen 153(CA153)and carcinoembryonic antigen(CEA)],quality of life,effective rate and occurrence of complications was compared between the two groups.Results After operation,the CEA(3.81±0.42)μg/L and CA153(26.15±3.29)U/ml in the observation group was lower than(4.06±0.67)μg/L and(27.49±2.04)U/ml in the control group,and their difference was statistically significant(P<0.05).The incision length,operation time and hospitalization time in the observation group was shorter than those in the control group,and amount of intraoperative hemorrhage and intraoperative drainage was less than those in the control group.Their difference was statistically significant(t=18.0937,15.6852,9.3692,9.2195,13.1309,P<0.05).The scores of physical ability,social field,emotional limitation and mental state in the observation group was higher than those in the control group,and the difference was statistically significant(t=8.1145,31.3441,5.7555,6.6572,P<0.05).The effective rate 92.86%in the observation group was higher than 76.19%in the control group,and the difference was statistically significant(χ^2=4.4594,P=0.0347<0.05).The incidence of complications 4.76%in the observation group was lower than 19.05%in the control group,and the difference was statistically significant(χ^2=4.0865,P=0.0432<0.05).Conclusion Breast conserving surgery can improve the overall effect of early breast cancer and the level of serum tumor markers,thus achieving good curative effect.