TIM-3 rs1036199基因多态性与类风湿关节炎发病风险相关性Meta分析

Association of TIM-3 rs1036199 polymorphisms with the onset risk of rheumatoid arthritis:a Meta analysis

目的探讨TIM-3 rs1036199基因多态性与类风湿关节炎(RA)易感性的关系。方法检索Pubmed、Embase、Web of Science、中国知网、万方数据及维普网等数据库中2018年8月28日之前发表的RA和TIM-3基因多态性相关文献,使用STATA软件进行Meta分析。纳入的7项研究共收集RA患者1267例,正常对照者1360名。结果TIM-3 rs1036199与RA发生风险无关[G相对于T:比值比(OR)=1.44,95%可信区间(CI)0.73~2.82;GT相对于TT:OR=1.46,95%CI 0.70~3.06]。根据人群进行亚组分析发现,韩国人群rs1036199多态性可显著增加RA风险(G相对于T:OR=1.61,95%CI 1.20~2.14;GT相对于TT:OR=1.71,95%CI 1.26~2.32)。根据对照来源不同进行亚组分析发现,以人群为基础的病例对照研究组rs1036199多态性可显著增加RA风险(G相对于T:OR=3.66,95%CI 1.90~7.04;GT相对于TT:OR=3.85,95%CI 1.98~7.48)。结论韩国人群rs1036199多态性是RA的危险因素,而中国人群rs1036199多态性与RA易感性是否有关仍不明确。

Objective To evaluate the association of TIM-3 rs1036199 polymorphisms with the susceptibility of rheumatoid arthritis(RA).Methods A systematic search of published studies related to the association of TIM-3 rs1036199 polymorphisms with RA was conducted in PubMed,Embase,Web of Science,CNKI,Wanfang and VIP databases(last updated on August 28,2018).A Meta analysis was performed using STATA software.A total of 7 studies including 1267 RA cases and 1360 healthy subjects were enrolled.Results TIM-3 rs1036199 polymorphism was not associated with RA in allele comparison[G to T:odds ratio(OR)=1.44,95%confidence interval(CI)0.73-2.82]and heterozygous comparison(GT to TT:OR=1.46,95% CI 0.70-3.06).Subgroup analysis based on ethnicity demonstrated that TIM-3 rs1036199 polymorphism was associated with RA in Korean(G to T:OR=1.61,95% CI 1.20-2.14;GT to TT:OR=1.71,95% CI 1.26-2.32).Subgroup analysis based on the source of control showed that TIM-3 rs1036199 polymorphism contributed to RA susceptibility in population based on case-control studies(G to T:OR=3.66,95% CI 1.90-7.04;GT to TT:OR=3.85,95% CI 1.98-7.48).Conclusions The present studies reveal that TIM-3 rs1036199 polymorphism is associated with RA in Korean,while the association of TIM-3 rs1036199 with RA in Chinese remains uncertain.