摘要
替加环素作为特殊级抗菌药物多在危重患者中和(或)其他抗菌药物治疗无效后使用。特殊人群、特殊病理生理状态的患者使药物呈现不同的药动学状态,同时医疗干预诸如连续性肾脏替代疗法(CRRT)、体外膜肺氧合(ECMO)使药动学改变更为复杂,影响用药的安全性和有效性,该文重点对这类特殊患者使用替加环素的药动学研究进行综述。
Tigecycline is used as a special grade antibacterial drug in critically ill patients and/or other antibacterial drugs are ineffective.However,special populations,patients with special pathophysiological status may present different pharmacokinetic(PK)status about tigecycline,such as patients with continuous renal replacement therapy(CRRT)or extracorporeal membrane oxygenation(ECMO)which make PK changes more complex and affect the safety and efficacy of medication.This article focuses on and summarizes the pharmacokinetic study of tigecycline in special patients.
作者
封永莉
边原
陈璐
李慧
舒永全
张丽娟
FENG Yongli;BIAN Yuan;CHEN Lu;LI Hui;SHU Yongquan;ZHANG Lijuan(Personalized Drug Therapy Key Laboratory of Sichuan Province,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 610072,China;Department of Hematology,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,Chengdu 610072,China)
出处
《医药导报》
CAS
北大核心
2020年第1期41-46,共6页
Herald of Medicine
基金
四川省科技计划重点研发项目(2019YFS0328)
四川省省级公益性科研院所基本科研业务专项课题(2018YSKY0017)
关键词
替加环素
特殊患者
药动学
Tigecycline
Special patients
Pharmacokinetic
