手术后肠梗阻药物治疗的研究进展

Research Advances in Drug Treatment of Postoperative Ileus

手术后肠梗阻(POI)是暂时性的胃肠动力障碍,无论是腹部手术还是非腹部手术均可发生,发生原因包括手术操作及手术中、手术后使用药物等。这些因素主要通过影响神经调节、增加炎症反应、调节胃肠激素等途径导致POI的发生发展。很多措施及药物可以降低POI的发生或缩短POI持续时间。在过去的十几年,治疗POI的药物研究取得了很大进步。该文综述已上市的促动力药物及传统复方药物对POI的疗效,介绍POI药物治疗现状,并整理分析POI治疗药物的研究方向,为POI的药物治疗提供参考。

Postoperative ileus(POI)is defined as transient impairment of gastrointestinal motility.It is commonly occurred in both abdominal and non-abdominal surgeries.There are many causes of POI,including the surgical procedure and the medicine applied in and after surgery.All of these factors accelerate POI mainly through affecting the physiology,increasing the inflammatory factors and regulating the gut hormones.Various agents and medicines have been studied so far in order to decrease the occurrence and the duration of POI.In the last decade,conspicuous progress has been made in medication treatment for POI.This review is in order to elaborating the current medicine treatment of POI by summarizing the effect of the prokinetic drugs that are already on the market and the traditional medicine on POI.In addition,we also sort out and analyze the research direction of the medicine for POI to take references for the drug treatment of POI.