肝硬化门静脉高压的无创评估

Noninvasive assessment of cirrhotic portal hypertension

肝静脉压力梯度测定(HVPG)是反映肝硬化门静脉高压程度的金标准,但其临床应用有一定限制,迫切需要门静脉高压的无创评估方法。简述了血清学、影像学、弹性成像等方法以及联合诊断模型,评述了现有的研究结果及不同方法的优缺点,认为无创诊断技术未来有可能在肝硬化门静脉高压患者的筛查监测和风险分层中起到更大的作用。

Hepatic venous pressure gradient(HVPG)is the gold standard for the degree of cirrhotic portal hypertension and has limited use in clinical application,and therefore,there is an urgent need for noninvasive assessment methods for portal hypertension.This article introduces various serological,imaging,and elastography methods and combined diagnostic models and elaborates on the current research results and the advantages and disadvantages of each method.It is pointed out that in future,noninvasive diagnostic techniques may play a greater role in screening,monitoring,and risk stratification of patients with cirrhotic portal hypertension.