中青年急性脑梗死与血清胱抑素C、尿酸及同型半胱氨酸水平的相关性分析

Correlations between Acute Cerebral Infarction and Serum Cystatin C,Uric Acid and Homocysteine Levels in Young and Middle-Aged Patients

目的探讨中青年急性脑梗死与血清胱抑素C、尿酸及同型半胱氨酸水平的相关性。方法选取139例中青年急性脑梗死患者为研究组,100例非脑梗死中青年患者为对照组,比较2组血清胱抑素C、尿酸、同型半胱氨酸、三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白等指标水平及高血压、糖尿病、吸烟、饮酒等情况,同时比较研究组不同性别间以上各项指标情况;采用Logisitc回归分析中青年脑梗死与血清胱抑素C、尿酸及同型半胱氨酸的相关性。结果研究组血清胱抑素C、尿酸、同型半胱氨酸、三酰甘油水平及吸烟、糖尿病、高血压比例均显著高于对照组,血清高密度脂蛋白水平显著低于对照组,差异具有统计学意义(P<0.05)。研究组男性患者血清尿酸、同型半胱氨酸水平及吸烟、饮酒比例均显著高于女性患者,差异具有统计学意义(P<0.05)。Logisitc回归分析显示,血清胱抑素C、尿酸及同型半胱氨酸水平与中青年脑梗死呈正相关(OR=6.538、1.005、1.092,95%CI:1.423~30.027、1.001~1.009、1.020~1.169,P=0.016、0.010、0.011)。结论血清胱抑素C、尿酸及同型半胱氨酸水平升高与中青年急性脑梗死的发生密切相关。

Objective To study the correlations between acute cerebral infarction and serum cystatin C,uric acid and homocysteine levels in young and middle-aged patients.Methods Serum levels of cystatin C,uric acid,homocysteine,total cholesterol,triglyceride,low density lipoprotein and high density lipoprotein and proportions of hypertensive patients,diabetic patients,smokers and drinkers were compared between 139 young and middle-aged patients with acute cerebral infarction(study group) and 100 patients without cerebral infarction(control group).In addition,these indexes were also compared between males and females in study group.Logistic regression analysis was performed to determine the correlations between acute cerebral infarction and serum cystatin C,uric acid and homocysteine levels. Results The levels of cystatin C,uric acid,homocysteine and triglyceride and the proportion of males in study group were higher than those in control group(P<0.05).Furthermore,serum high density lipoprotein level in study group was lower than that in control group(P<0.05).In study group,the proportions of smokers and drinkers in males were higher than those in females(P<0.05).Logistic regression analysis showed that serum cystatin C,uric acid and homocysteine levels were positively correlated with acute cerebral infarction in young and middle-aged patients(OR=6.538,1.005 and 1.092,respectively;95%CI:1.423-30.027,1.001-1.009 and 1.020-1.169,respectively;P=0.016,0.010 and 0.011,respectively).Conclusion The elevated levels of serum cystatin C,uric acid and homocysteine were closely related to acute cerebral infarction in young and middle-aged people.