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非酒精性脂肪性肝病与丙型肝炎 被引量:9

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摘要 非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝脏损伤,患者无过量饮酒史,疾病谱包括非酒精性单纯性脂肪肝(non-alcoholic simple fatty liver,NAFL)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)及其相关肝硬化和肝细胞癌。NAFLD在欧美等西方发达国家普通成人患病率为20%~33%,其危险因素包括高脂肪高热量膳食结构、多坐少动的生活方式、胰岛素抵抗、代谢综合征及其组分(肥胖、高血压、血脂异常和2型糖尿病)。NAFLD病理特征为肝腺泡3区大泡性或以大泡为主的混合性肝细胞脂肪变,伴或不伴有肝细胞气球样变、小叶内混合性炎症细胞浸润及窦周纤维化[1]。
出处 《中国临床医生杂志》 2020年第1期10-12,共3页 Chinese Journal For Clinicians
基金 国家自然科学基金项目(81770577、81500439) 北京市医院管理局重点医学专业发展计划(ZYLX201808) 北京市医院管理局消化内科学科协同发展中心消化专项重点项目(XXZ0402) 北京市科学技术委员会科技计划重大项目(D171100003117005)
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