异甘草酸镁治疗肝癌肝动脉栓塞化疗肝损伤的临床观察

Clinical observation of magnesium isoglycolate in the treatment of liver injury caused by hepatic artery embolization and chemotherapy for liver cancer

目的:分析异甘草酸镁治疗肝癌肝动脉栓塞化疗肝损伤的临床应用效果.方法:2018年1月-2019年1月收治肝癌肝动脉栓塞化疗肝损伤患者56例,分为两组各28例.参照组使用甘草酸二铵注射液治疗;试验组使用异甘草酸镁治疗.比较两组肝功能变化情况、临床治疗情况及不良反应发生率.结果:两组治疗前谷丙转氨酶(ALT)与碱性磷酸酶(ALP)水平比较,差异无统计学意义(P>0.05);两组治疗后肝功能指标均明显降低,且试验组ALT与ALP水平降低幅度更大,差异有统计学意义(P<0.05).试验组症状缓解率优于参照组,差异有统计学意义(P<0.05).试验组治疗期间不良反应发生率低于参照组,差异有统计学意义(P<0.05).结论:异甘草酸镁治疗肝癌肝动脉栓塞化疗肝损伤的效果较好,可提升患者治疗有效率,改善患者肝功能状态,且治疗期间不良反应发生率低.

Objective:To explore the clinical effect of magnesium isoglycolate in the treatment of liver injury caused by hepatic artery embolization and chemotherapy for liver cancer.Methods:From January 2018 to January 2019,56 patients with injury caused by hepatic artery embolization and chemotherapy for liver cancer were selected and divided into two groups with 28 cases in each group.The control group was treated with diammonium glycyrrhizinate injection,and the test group was treated with magnesium isoglycyrrhizate.We compared the changes of liver function,clinical treatment and the incidence of adverse reactions between the two groups.Results:Before treatment,there was no significant difference in ALT and ALP between the two groups(P>0.05).After treatment,the liver function indexes of the two groups were significantly reduced,and the ALT and ALP levels of the experimental group were significantly reduced,the difference was statistically significant(P<0.05).The symptom relief rate of the experimental group was better than that of the reference group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The clinical effect of magnesium isoglycolate in the treatment of liver injury caused by hepatic artery embolization and chemotherapy for liver cancer was better,it can improve the treatment efficiency,improve the liver function of patients,and the incidence of adverse reactions during the treatment was low.