尿液膀胱肿瘤抗原水平检测在膀胱癌诊断中的意义

Significance of Urine Bladder Tumor Antigen Level in the Diagnosis of Bladder Cancer

目的评估尿液膀胱肿瘤抗原(BTA)水平在膀胱癌诊断中的价值。方法收集98例膀胱癌患者、57例非膀胱癌患者以及68例健康体检者晨尿标本,利用化学发光分析仪进行各样本中BTA水平的检测。通过ROC曲线下面积计算,分析BTA对膀胱癌的诊断灵敏度、特异度及最佳临界值。结果膀胱癌患者尿液中BTA水平[486.56(66.27,2 013.81)] U/ml明显高于健康对照组[25.71(10.40,53.39)] U/ml及非膀胱癌组[55.47(26.55,296.24)] U/ml,差异具有统计学意义(χ^2=64.172,P<0.01);BTA诊断膀胱癌的ROC曲线下面积为0.816,与参考线下面积相比,差异具有统计学意义(P<0.01),BTA诊断膀胱癌的最佳临界值为84.38U/ml,诊断敏感度为70.8%,特异度为93.5%。结论尿液BTA的检测在膀胱癌的诊断筛查中具有较高的临床价值,可用于膀胱癌的早期筛查。

Objective To evaluate the application value of urinary bladder tumor antigen(BTA)detection in the diagnosis of bladder cancer.Methods The morning urine was collected respectively from the 98 bladder cancer samples,57 patients with non-bladder cancer,and 68 healthy subjects.The level of BTA was detected using a chemiluminescence analyzer.Through the calculation of the area under the ROC curve,analyzed the sensitivity,specificity and optimal threshold of BTA for the diagnosis of bladder cancer.Results The level of BTA in the urine of patients with bladder cancer[486.56(66.27,2013.81)]U/ml was significantly higher than that of the normal control group[25.71(10.40,53.39)]U/ml and non-bladder cancer patients group[55.47(26.55,296.24)]U/ml,and significant difference was shown(χ^2=64.172,P<0.01).The area under the ROC curve for the diagnosis of bladder cancer of BTA was 0.816,compared with the area under the reference line,which was significant difference(P<0.01).The cut-off value for BTA diagnosis of bladder cancer was 84.38 U/ml,the diagnostic sensitivity was 70.8%,and the specificity was 93.5%.Conclusion Detection of urinary BTA has a higher clinical value in the diagnosis of bladder cancer,and can be used for early screening of bladder cancer.