生物可降解聚酯乙交酯丙交酯共聚物中溶剂残留测定

Determination of residual solvents in biodegradable poly(lactide-co-glycolide)

采用DB-624(30 m×530μm×3.0μm)毛细管色谱柱,氢火焰离子化检测器(FID),顶空进样,建立了乙交酯丙交酯共聚物(PLGA)中残留溶剂测定方法。试验结果表明,该方法测得各溶剂在考察浓度范围内峰面积与质量浓度呈现良好的线性关系,回收率在98.54%~99.50%,精密度RSD均小于2%,定量限在0.16~1.17μg/mL。本方法操作简单、结果准确、重现性好,可用于PLGA中乙醇、丙酮、二氯甲烷和乙酸乙酯残留溶剂的同时测定。

A headspace gas chromatography method was established for the determination of residual solvents in poly(lactide-co-glycolide).The method was programmed with DB-624 capillary column(30m×530μm×3.0μm)and flame ionization detector(FID).The results showed that the standard curves were linear in the range of experimental concentration,the average recoveries for four residual solvents were between 98.54%and 99.50%,the RSDs of precision was all less than 2%,the quantitation limits were 0.16μg/ml^1.17μg/ml.The method is rapid,sensitive and accurate.It can be used for the determination of ethanol,acetone,dichloromethane and acetic ether in poly(lactide-co-glycolide)at the same time.