孤立性纤维性肿瘤的诊断和治疗——单中心回顾性研究

Diagnosis and treatment of solitary fibrous tumors-a single-center retrospective study

目的探讨孤立性纤维性肿瘤的诊断、治疗方法和随访。方法回顾我院7年半收治的经手术切除并病理确诊为孤立性纤维性肿瘤的病例资料,就其流行病学特点、诊断、治疗方法和随访进行总结与分析。结果 60例孤立性纤维性肿瘤患者,男女比例无明显差异,中位年龄为46岁。盆腹腔为最常见的发病部位,其次为颅内、耳鼻喉口腔。约一半的患者出现专科症状而就诊。所有病例均行手术切除,并经病理组织学检查和免疫组化染色确诊。27例(45%)患者术后进行了复查随访,且多为1年内。27例中有4例在复查随访时发现复发。结论孤立性纤维性肿瘤大多为良性或低度恶性,生长较缓慢,诊断主要依赖组织学和免疫组化染色确诊,手术完整切除是其主要治疗手段,术后应定期进行随访复查。

Objective To explore the diagnosis,treatment and follow-up of solitary fibrous tumors(SFT).Methods The clinical data for seven and a half years in our institution of solitary fibrous tumors,which were surgically resected and pathologically diagnosed,were collected,and epidemiological characteristics,diagnosis,therapies and follow-up of SFT were analyzed and summed up.Results There was no significant difference in the ratio of male to female of 60 SFT patients and the median age was 46 years old.Pelvic and abdominal cavities were the most common site,followed by intracranial space,otolaryngology and oral cavity.About half of patients came to the hospital with specialized symptoms.All cases were surgically resected and confirmed by histopathology and immunohistochemical staining.45% of the patients were reexamined and followed up postoperatively almost in one year.Recurrence was found in 4 of the 27 patients at follow-up.Conclusion Solitary fibrous tumors are mostly benign or low-grade malignant and grow slowly.Its diagnosis depends on histopathology and immunohistochemical staining.Complete surgical resection is the main treatment,and follow-up should be carried out regularly.