血清SCC、CEA、CA125与CA19-9水平联合检测对早期宫颈癌患者诊断应用价值

Diagnostic Application Value of Serum SCC,CEA,CA125 and CA19-9 Joint Detection forEarly Cervical Cancer Patients

目的探讨早期宫颈癌采用血清SCC、CEA、CA125与CA19-9联合诊断的临床价值及对准确率的影响。方法选取2017年8月~2018年2月我院收治的早期宫颈癌患者105例为观察组,选取同期105例健康志愿者为对照组,抽取两组静脉血样测定血清SCC、CEA、CA125、CA19-9水平,统计阳性率,评价单一指标与联合指标诊断早期宫颈癌的灵敏度与特异度。结果观察组SCC、CEA、CA125、CA19-9平均血清水平及指标阳性率均高于对照组,差异有统计学意义(P<0.05);SCC、CEA、CA125、CA19-9联合诊断早期宫颈癌灵敏度与准确率均高于各指标单一诊断结果(P<0.05),特异度与各指标单一诊断结果比较差异无统计学意义(P>0.05)。结论血清SCC、CEA、CA125与CA19-9联合检测可提高早期宫颈癌诊断准确度,值得临床推广使用。

Objective To investigate the clinical value and accuracy of combined diagnosis of SCC、CEA、CA125 and CA19-9 in early cervical cancer patients.Methods 105 patients with early cervical cancer in our hospital from August 2018 to February 2019 were selected as the experimental group and 105 healthy volunteers in the same period as the control group.The levels of serum SCC、CEA、CA125 and CA19-9 were measured by venous blood samples from two groups.The positive rates were counted and the diagnostic accuracy was observed.Results The average serum levels and positive rates of SCC、CEA、CA125 and CA19-9 in the experimental group were higher than those in control group(P<0.05);The sensitivity and accuracy of combined diagnosis of SCC、CEA、CA125 and CA19-9 in early cervical cancer were higher than those of single diagnosis of each index(P<0.05),and the specificity was similar to that of single diagnosis of each index(P>0.05).Conclusions The combined detection of serum SCC、CEA、CA125 and CA19-9 can improve the diagnostic accuracy in early cervical cancer patients,which is worthy of clinical application.