9%吡唑醚菌酯微囊悬浮剂的制备与性能研究

Preparation and Property of Pyraclostrobin 9% CS

采用界面聚合法,制备了以聚脲为囊壁材料的9%吡唑醚菌酯微囊悬浮剂。考察了囊芯溶剂种类、乳化剂种类、芯壁比、固化温度和固化时间等因素对微囊粒径和稳定性的影响。通过光学显微镜、激光粒度仪、红外光谱、高效液相色谱仪和扫描电镜等仪器对所制备的微囊悬浮剂进行性能表征测定。以斑马鱼作为试验对象,对制剂毒性进行研究。结果表明,囊芯溶剂选用150#溶剂油,乳化剂选用SP-7125,用量为水相质量的2.5%;芯壁比为100∶3;固化温度65℃,固化时间6.5 h。此条件下制备得到的微囊表面光滑,形态圆整,平均粒径2.5μm,包封率大于90%,贮存稳定性合格。与悬浮剂相比,所制备的9%吡唑醚菌酯微囊悬浮剂对斑马鱼的毒性明显降低。

Pyraclostrobin 9%CS with polyurea material was prepared by interfacial polymerization.It was investigated in the effects of core solvent type,emulsifier type,core wall mass ratio,curing temperature,and curing time on the particle size and stability of microcapsules.The properties of microcapsule suspension were characterized by using optical microscopy,laser particle size analysis,infrared spectroscopy,high-performance liquid chromatography,and scanning electron microscopy.In addition,zebrafish was used as the experimental object to study the toxicity of the preparation.The results showed that 150#solvent-oil was selected as the core solvent,SP-7125 was used as the emulsifier,and the dosage of the water phase mass was 2.5%.The mass ratio of core wall was 100∶3.The curing temperature was 65℃,and the time was 6.5 h.The microcapsule suspension prepared with the above scheme was provided with spherical shape in a smooth surface in stability when storage.The average particle size was 2.5μm,and the encapsulation efficiency was above 90%.Compared with the suspension,the prepared pyraclostrobin microcapsule suspension reduced the toxicity to zebrafish significantly.