摘要
目的分析基于基因组学技术的疾病生物标志物研究的热点和趋势,探讨国内外的研究现状和研究趋势,为该领域后续研究提供依据。方法以Web of Science数据库为数据源,采用文献计量方法和CiteSpace软件,对2006至2018年基因组学疾病标志物研究领域的发文国家和机构、知识基础、研究热点及研究趋势等指标进行统计分析。结果共检索到基因组学疾病标志物研究领域文献998篇,载文量总体呈上升趋势,2017和2018年的发文量达到最高值112篇;美国的载文数量(477篇)最多,中国(93篇)排名第2;Nature、P Natl Acad Sci USA、PLoS One、Science和New Engl J Med等是该研究领域的核心期刊;关键词共现分析将研究热点分为疾病研究、研究方法及技术、研究水平和应用目的。结论功能基因组学研究、癌症免疫疗法、全基因组关联和多组学技术、个体化医疗与精准医学是该领域的研究趋势。
Objective To analyze the research hotspots and trends of biomarkers for diseases based on genomics and thus provide basis for the future studies in this field.Method Based on the Web of Science,we analyzed the genomics-based biomarkers for diseases in literature published between 2006 and 2018 in terms of country and institutions,knowledge base,research hotspots,and trends by using bibliometric methods and CiteSpace software.Results A total of 998 articles were retrieved.The total number of articles has shown an upward trend and reached a peak of 112 in 2017 and 2018.Most articles(n=477)were from the United States,follwed by China(n=93).Nature,P Natl Acad Sci USA,PLoS One,Science,and New Engl J Med are core journals in this field.Keywords co-occurrence analysis identified four research hotspots:disease research,research method and technology,research level,and application purpose.Conclusion Research in functional genomics,cancer immunotherapy,genome-wide association and multi-omics techniques,personalized medicine,and precision medicine are research hotspots and frontiers in this field.
作者
刘姬艳
贺琳娟
杨艳宏
王晓迪
LIU Jiyan;HE Linjuan;YANG Yanhong;WANG Xiaodi(Department of Academic Journals,Hangzhou Normal University,Hangzhou 311121,China;College of Life and Environmental Science,Hangzhou Normal Univeresity,Hangzhou 310036,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2019年第6期806-812,共7页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81403280)
浙江省科技计划项目(2015C33266)
杭州市科技发展计划项目(20150633B01)~~