益生菌治疗细菌性阴道炎效果的Meta分析

Effect of probiotics on bacterial vaginosis:A meta-analysis

目的对益生菌治疗细菌性阴道炎的效果进行系统评价和Meta分析,以期指导妇科临床合理使用益生菌治疗细菌性阴道炎及后续的随机对照临床试验的设计。方法以"益生菌"、"细菌性阴道炎"等关键词检索3个英文数据库和4个中文数据库,通过筛选共纳入5篇随机对照试验文献进行Meta分析。选取益生菌治疗细菌性阴道炎的治愈率效果作为结局指标,采用随机或固定效应模型进行分析。结果 Meta分析结果显示,相比安慰剂,益生菌在治愈细菌性阴道炎效果方面与其不存在显著差异。此外,无论是口服还是阴道局部使用益生菌均无不良反应发生。结论单纯使用益生菌治疗细菌性阴道炎的安全性好,治愈效果欠佳,但还需更多严谨设计的多中心大样本的随机对照临床试验进一步验证其疗效。

Objective To guide rational gynecological use of probiotics in the treatment of bacterial vaginosis and the design of randomized controlled trials, the effect of probiotics on bacterial vaginosis was evaluated by meta-analysis. Methods Three English databases and four Chinese databases were searched by applying keywords such as "probiotics" and " bacterial vaginosis". Five RCTs were included and meta-analysis was conducted. The cure rate of bacterial vaginosis was selected as the outcome. The random or fixed effect model was selected depends on heterogeneity. Results The meta-analysis demonstrated that probiotics group significantly differed in the cure rate of bacterial vaginosis compared with placebo group. In addition, no side effect was observed in oral or vaginal topical adminstration of probiotics. Conclusion Probiotics is a safe but not effective treatment for bacterial vaginosis. However, more strict design and multi-center large scale randomized controlled clinical trials are required to verify this study.