摘要
基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)作为一种趋化因子及其受体CXC趋化因子受体4型(chemokine receptor-4,CXCR4)在骨性关节炎(osteoarthritis,OA)的发生发展中起重要作用。SDF-1与CXCR4的结合可激活多种下游信号通路,形成复杂的信号网络,随着对有关该信号网络的深入研究,将会对骨性关节炎的发病机制有更加深入的了解,同时也会对骨性关节炎的治疗寻找到新的靶点。
Stromal cell-derived factor-1(SDF-1),as a chemokine and its receptor CXC chemokine receptor type 4(CXCR4),plays an important role in the occurrence and development of OA. The combination of SDF-1 and CXCR4 activates a variety of downstream signaling pathways,involving a variety of cytokines,forming a complex signaling network. As the signal network is further studied,the etiology and mechanism of osteoarthritis will be deepened. At the same time,new therapeutic targets for osteoarthritis will be discovered.
作者
何映红
李彦林
向耀宇
陈泳佳
杨骁
HE Yinghong;LI Yan?lin;XIANG Yaoyu;CHEN Yongjia;YANG Xiao(Department of Sports Medicine,the First Affiliated Hospital of Kunming Medical University,Kunming 655031,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第22期3563-3567,共5页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81760403)
昆明医科大学创新基金项目(编号:2019S121)