SDF-1/CXCR4及下游信号通路在骨性关节炎病程中的作用

The role of SDF-1/CXCR4 and downstream signaling pathways in the course of OA

基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)作为一种趋化因子及其受体CXC趋化因子受体4型(chemokine receptor-4,CXCR4)在骨性关节炎(osteoarthritis,OA)的发生发展中起重要作用。SDF-1与CXCR4的结合可激活多种下游信号通路,形成复杂的信号网络,随着对有关该信号网络的深入研究,将会对骨性关节炎的发病机制有更加深入的了解,同时也会对骨性关节炎的治疗寻找到新的靶点。

Stromal cell-derived factor-1(SDF-1),as a chemokine and its receptor CXC chemokine receptor type 4(CXCR4),plays an important role in the occurrence and development of OA. The combination of SDF-1 and CXCR4 activates a variety of downstream signaling pathways,involving a variety of cytokines,forming a complex signaling network. As the signal network is further studied,the etiology and mechanism of osteoarthritis will be deepened. At the same time,new therapeutic targets for osteoarthritis will be discovered.