肝移植时代胆管恶性肿瘤的外科治疗研究进展

Progress in surgical treatment of biliary malignant tumors in the era of liver transplantation

近年来,胆管癌的全球发病率持续增高。依据发生部位不同,胆管癌可被分为肝内、肝门部和远端胆管癌3种亚型,其中肝内和肝门部胆管癌均曾一度被认为是肝移植术治疗的禁忌证。不过,随着医学和新辅助治疗的发展,上述2种亚型胆管癌患者现亦有望接受肝移植术治疗了。本文通过文献复习并结合笔者经验,就肝移植术在胆管恶性肿瘤外科治疗中的应用现状和研究进展作一概要介绍。

The incidence of cholangiocarcinoma has been increasing worldwide in recent years.Cholangiocarcinoma can be divided into intrahepatic cholangiocarcinoma(iCCA),perihilar cholangiocarcinoma(pCCA)and distal cholangiocarcinoma according to the location of the tumors.The two subtypes of cholangiocarcinoma such as iCCA and pCCA which once considered as contraindications of liver transplantation can now be treated by transplantation with the recent development of medical research and neoadjuvant therapy.The application status and research progress of liver transplantation in the treatment of malignant bile duct tumors are briefly introduced in this review based on the literature and our experience.