重组人干扰素α-2b对流行性腮腺炎患儿血清TNF-α、CRP及WBC水平的影响

Effect of recombinant human interferon α-2b on TNF-α, CRP and WBC in children with mumps

目的:探讨重组人干扰素α-2b对流行性腮腺炎患儿血清肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)、白细胞(WBC)的影响。方法:选取我院收治的98例流行性腮腺炎患儿,随机分为对照组和观察组各49例。对照组行利巴韦林治疗,在此基础上,观察组加用重组人干扰素α-2b治疗,对比两组临床疗效、血清TNF-α、CRP及WBC水平。结果:治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、CRP水平较对照组低,WBC水平较对照组高,差异有统计学意义(P<0.05)。结论:重组人干扰素α-2b对流行性腮腺炎患儿治疗效果显著,可改善血清TNF-α、CRP、WBC水平。

Objective:To investigate the effect of recombinant human interferonα-2b on tumor necrosis factorα(TNF-α),C-reactive protein(CRP)and white blood cell(WBC)in children with mumps.Methods:Ninety-eight children with mumps treated in our hospital were selected and randomly divided into a control group and an observation group with 49 cases each.Control group was given ribavirin and observation group was treated with recombinant human interferonα-2b besides.The clinical efficacy,serum TNF-α,CRP and WBC levels were compared between the two groups.Results:After treatment,the total effective rate and WBC level were higher and TNF-αand CRP levels were lower in the observation group than the control group(P<0.05).Conclusion:Recombinant human interferonα-2b for the treatment of children with mumps is effective and can improve the levels of serum TNF-α,CRP and WBC.