重组人干扰素α2a栓联合聚甲酚磺醛溶液治疗宫颈柱状上皮异位合并高危HPV感染的效果

Effect of recombinant human interferon α2a suppository combined with policresulen solution in the treatment of cervical columnar epithelial ectopia with high risk HPV infection

目的探究重组人干扰素α2a栓联合聚甲酚磺醛溶液治疗宫颈柱状上皮异位合并高危人类乳头状瘤病毒(HPV)感染的效果。方法选取2017年1月至2018年12月于我院就诊的109例宫颈柱状上皮异位合并高危HPV感染患者为研究对象,按照就诊顺序将患者分为参照组(54例)和研究组(55例)。参照组患者给予重组人干扰素α2a栓治疗,研究组患者在参照组基础上加用聚甲酚磺醛溶液治疗。比较两组患者治疗前、后的免疫功能、临床症状改善时间及治疗前、后的血清病毒载量。结果治疗前,两组患者的CD3^+、CD4^+、CD8^+水平、CD4^+/CD8^+、血清病毒载量比较,差异无统计学意义(P>0.05);治疗后,两组患者的CD3^+、CD4^+水平、CD4^+/CD8^+均明显高于治疗前,CD8^+水平明显低于治疗前,且研究组优于参照组(P<0.05)。研究组患者的糜烂创面愈合时间、阴道分泌物、白带异常和小腹坠胀消失时间均明显短于参照组(P<0.05)。治疗后,两组患者的血清病毒载量明显低于治疗前,且研究组明显低于参照组(P<0.05)。结论重组人干扰素α2a栓联合聚甲酚磺醛溶液治疗宫颈柱状上皮异位合并高危HPV感染可提高患者机体的免疫功能,改善患者临床症状,清除血清病毒,值得临床推广应用。

Objective To explore the effect of recombinant human interferon α2a suppository combined with policresulen solution in the treatment of cervical columnar epithelial ectopia with high-risk human papillomavirus(HPV) infection.Methods From January 2017 to December 2018, 109 patients of cervical columnar epithelial ectopia with high-risk HPV infection treated in our hospital were selected as the study objects, the patients were divided into reference group(54 cases)and study group(55 cases) according to the order of admission. Patients in the reference group were treated with recombinant human interferon α2a suppository, while patients in the study group were treated with policresulen solution on the basis of the control group. The immune function before and after treatment, improvement time of clinical symptoms and serum viral load before and after treatment were compared between the two groups. Results Before treatment, there were no significant differences in the levels of CD3^+, CD4^+, CD8^+, CD4^+/CD8^+ and serum viral load between the two groups(P>0.05).After treatment, the levels of CD3^+, CD4^+ and CD4^+/CD8^+ in both groups were significantly higher than those before treatment, and the levels of CD8^+ were significantly lower than those before treatment, those in the study group were better than the reference group(P <0.05). The healing time of erosive wound, the disappearance times of vaginal secretion,leucorrhea abnormality and abdominal distention in the study group were significantly shorter than those in the reference group(P<0.05). After treatment, the serum viral load of the two groups were significantly lower than those before treatment,and that in the study group was significantly lower than the reference group(P <0.05). Conclusion Recombinant human interferon α2a suppository combined with policresulen solution in the treatment of cervical columnar epithelial ectopia with high-risk HPV infection can improve the immune function of patients, and the clinical symptoms of patients and remove the serum virus, which is worth promoting and applying in clinic.