皮炎湿疹发病机制中Th1/Th2细胞因子水平的变化及其临床意义分析

Changes of Th1/Th2 cytokines in patients with dermatitis and eczema and their clinical significance

目的:探讨皮炎湿疹发病机制中Th1/Th2细胞因子水平的变化及其临床意义。方法:选取2017-01~2018-12我院收治的皮炎湿疹患者40例,其中包含接触性皮炎患者28例,湿疹患者12例,以及同期来我院进行健康体检的健康人20例作为健康对照组,分析Th1/Th2与皮炎湿疹发病机制的关系以及临床检测的意义。结果:接触性皮炎患者血清IFN-α高于健康对照组(P<0.05),接触性皮炎患者血清IL-4低于健康对照组(P<0.05),接触性皮炎患者血清IL-10与健康对照组无明显差异(P>0.05);湿疹患者血清IFN-α、IL-10高于健康对照组(P<0.05),湿疹患者血清IL-4低于健康对照组(P<0.05);湿疹患者与接触性皮炎患者血清IFN-γ、IL-4以及IL-10水平无明显差异(P>0.05)。结论:在皮炎湿疹患者的发病过程中,Th1细胞因子发挥着非常重要的作用,对于皮炎湿疹患者进行Th1/Th2检测可以判断患者疾病发展程度以及治疗效果。

Objective: To investigate the changes of Th1/Th2 cytokines in patients with dermatitis and eczema and its clinical significance.Methods: Twenty-eight patients with contact dermatitis, 12 patients with eczema and 20 healthy subjects in the control group who underwent physical examination at the same time were selected from January 2017 to December 2018 for comparative study, and the relationship between Th1/Th2 factor and the pathogenesis of dermatitis and eczema as well as the significance of clinical detection were analyzed.Results: Serum IFN-α of contact dermatitis patients was higher than that of healthy control group(P<0.05), serum il-4 was lower than that of healthy control group(P<0.05), and serum il-10 was not significantly different from that of healthy control group(P>0.05).Serum il-4 of eczema patients was lower than that of healthy control group(P<0.05), but serum IFN-α and il-10 were higher than that of healthy control group(P<0.05).There was no significant difference in serum levels of IFN-α, il-4 and il-10 between eczema patients and contact dermatitis patients(P>0.05).Conclusion: Th1 cytokine plays a lifting role in the pathogenesis of dermatitis and eczema. The detection of Th1/Th2 in patients with dermatitis and eczema can determine the disease progression and prognosis of patients.