miRNAs在高级别浆液性卵巢癌中的作用

Role of MicroRNAs in High-Grade Serous Ovarian Cancer

卵巢癌早期临床症状及体征表现不明显,发病机制复杂,目前仍缺乏有效的早期诊断及治疗的手段,病死率远高于其他妇科恶性肿瘤。高级别浆液性卵巢癌是临床中最常见、恶性程度最高的卵巢癌。微RNA(miRNA)是一种小的内源性非编码RNA分子,主要通过抑制翻译或降解靶标信使RNAs进而调节相关基因的表达。miRNA可以作为肿瘤抑制因子或致癌基因参与肿瘤的发生、发展,在恶性肿瘤的诊断、治疗和预后中发挥重要作用。而失调的miRNA与卵巢恶性肿瘤的发生、发展密切相关。

The early clinical symptoms and signs of ovarian cancer are not obvious,and the pathogenesis is complicated.There is still no effective early diagnosis and treatment means,and the mortality rate is much higher than other malignant gynecologic tumors.High-grade serous ovarian cancer is the most common and malignant ovarian cancer in the clinic.MicroRNA(miRNA)are small,endogenous,non-coding RNA molecules that regulate the expression of related genes primarily by inhibiting translation or degradation of target messenger RNAs.miRNA can be involved in the development of tumors as tumor suppressor or oncogene,and play an important role in the diagnosis,treatment and prognosis of malignant tumors.Dysregulated miRNA are closely related to the occurrence and development of ovarian malignancies.