新生儿先天性甲状腺功能减退发生的影响因素分析

Analysis on Influencing Factors of Neonatal Congenital Hypothyroidism

目的探讨先天性甲状腺功能减退发生的相关因素。方法选择2015年6月至2018年3月在绵阳市第三人民医院接受治疗的93例新生儿先天性甲状腺功能减退患儿作为观察组,将同期分娩的52例健康新生儿作为对照组,分析先天性甲状腺功能减退发生的相关因素。结果观察组患儿家族病史、母亲高龄、出生体重非正常(低体重)、农村户籍占比均高于对照组(P<0.05);经Logistic回归分析显示,家族病史、母亲高龄、出生体重(低体重)、农村户籍为新生儿先天性甲状腺功能减退发生的危险因素(P<0.05)。结论家族病史、母亲高龄、低体重儿为新生儿先天性甲状腺功能减退发生的相关因素,临床可通过加强健康宣讲、孕前、孕期筛查等干预措施,以进一步控制该病发生率,提高分娩质量。

Objective To investigate the relevant factors of congenital hypothyroidism.Methods A total of 93 cases of neonatal congenital hypothyroidism treated in Mianyang Third People′s Hospital from Jun.2015 to Mar.2018 were included as an observation group,and 52 healthy newborns delivered in the hospital during the same period were included as a control group.The relevant factors of neonatal congenital hypothyroidism were analyzed.Results The proportion of family medical history,advanced maternal age,abnormal birth weight(low birth weight),and rural household registration in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);Logistic regression analysis showed that family medical history,advanced maternal age,birth weight(low birth weight),and rural household registration were risk factors for neonatal congenital hypothyroidism(P<0.05).Conclusion Family medical history,advanced maternal age,low birth weight are related factors for neonatal congenital hypothyroidism.Clinically,interventions such as health education,pre-pregnancy and pregnancy screening can be strengthened to further control the incidence of the disease and improve the quality of delivery.