房颤相关TBX5基因单核苷酸多态性临床意义

Clinical significance of single nucleotide polymorphism of TBX5 gene associated with atrial fibrillation

目的了解房颤与TBX5基因单核苷酸多态性(SNP)的关联性。方法选取房颤患者92例及无房颤患者(对照组)93例,提取外周血基因组DNA,行TBX5基因rs3825214位点的SNP检测。结果 TBX5基因rs3825214位点呈多态性表现(AA、AG和GG型),房颤组和对照组基因型分布差异有统计学意义(P<0.05);房颤组等位基因以G为主,对照组等位基因以A为主(P<0.05);TBX5基因SNP对房颤发生有影响(P<0.05)。结论房颤与TBX5基因rs3825214位点多态性相关,GG基因型人群房颤发生率可能增高,G等位基因或为房颤易感基因。

Objective To understand the association between atrial fibrillation and single nucleotide polymorphism(SNP) of TBX5 gene.Methods A total of 92 patients with atrial fibrillation and 93 patients without atrial fibrillation(control group) were enrolled. The peripheral blood genomic DNA was extracted and the SNP of TBX5 gene rs3825214 was detected. Results The rs3825214 locus of TBX5 gene showed polymorphism(AA, AG and GG). The distribution of genotypes in the atrial fibrillation group and the control group was statistically significant(P<0.05).The allele in the atrial fibrillation group was mainly G. The control group alleles were mainly A(P<0.05). TBX5 gene SNP had an effect on atrial fibrillation(P<0.05). Conclusion Atrial fibrillation is associated with rs3825214 polymorphism in TBX5 gene. The incidence of atrial fibrillation may be increased in GG genotype, and G allele may be a susceptible gene.