卡马西平导致药物剥脱性皮炎的临床分析

Clinical analysis of carbamazepine leading to drug exfoliative dermatitis

目的探究卡马西平导致药物剥脱性皮炎的临床情况以及治疗分析情况。方法选择在2017年6月至2018年11月本院收治的86例应用卡马西平药物进行治疗的患者作为研究对象,按照随机数字法将患者分为观察组和对照组,各43例,其中观察组患者均为服用卡马西平药物导致药物剥落性皮炎等不良反应较重的患者,对照组患者均为服用卡马西平药物出现不良反应程度较轻的患者。比较分析两组患者在皮肤不良反应出现时间、不良反应类型方面的差异。结果两组在治疗后3、4、5、7周的不良反应发生率比较,差异不具有统计学意义。两组斯-章氏综合征、大疱性表皮松解型、麻疹样或猩红热样型、荨麻疹型、剥落性皮炎等不良反应发生率比较,差异不具有统计学意义。结论卡马西平导致药物剥脱性皮炎的临床情况需要进行进一步的研究,为了减少不良反应的发生需要联合其他药物进行治疗,为今后的相关研究提供借鉴。

Objective To investigate the clinical situation and treatment analysis of carbamazepine leading to drug-exfoliative dermatitis.Methods 86 patients who were treated with carbamazepine medication between June 2017 and November 2018 were selected as subjects. The patients were divided into observation group and control group according to random number method, with 43 cases in each group. The patients in the observation group were all with serious adverse reactions such as drug exfoliative dermatitis after taking carbamazepine drugs, and the patients in the control group all with light adverse reactions after using carbamazepine drugs. The differences in the incidence of adverse skin reactions and the types of adverse reactions between the two groups were compared. Results There was no significant difference in adverse reactions between the two groups at 3, 4, 5, and 7 weeks after treatment. The incidence of adverse reactions such as schizophrenia syndrome, bullous epidermolytic, measleslike or scarlet fever, urticaria, and exfoliative dermatitis was similar, and the difference was not statistically significant. Conclusion The clinical situation of carbamazepine leading to drug-exfoliative dermatitis requires further research. In order to reduce the occurrence of adverse reactions, it should be combined with other drugs to ensure that it can provide reference for future research.