急性心肌梗死患者cd42b、cd62p、Hcy及hs-CRP与冠状动脉病变程度的相关性

Correlation between cd42b, cd62p, Hcy, hs-CRP and the severity of coronary artery disease in patients with acute myocardial infarction

目的:研究急性心肌梗死(AMI)患者cd42b、cd62p、同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)与冠状动脉病变程度的相关性。方法:纳入2016年1月至2018年9月于邯郸市第一医院治疗的AMI患者154例,并依据Gensini评分分为L组(≤55分)、M组(56~84分)和H组(85~172分)。比较3组患者cd42b、cd62p、Hcy及hs-CRP的水平差异。比较不同冠状动脉病变支数患者cd42b、cd62p、Hcy及hs-CRP水平的差异。对cd42b、cd62p、Hcy及hs-CRP与冠状动脉病变程度的相关性进行分析。结果:3组间cd62p、Hcy和hs-CRP水平差异均有统计学意义(P<0.05),其中M组cd62p、Hcy和hs-CRP水平均显著高于L组(P<0.05),H组cd62p、Hcy和hs-CRP水平均显著高于L组和M组(P<0.05)。3组间cd42b水平差异无统计学意义。不同病变支数cd62p、Hcy及hs-CRP水平差异有统计学意义(P<0.05),病变数2支和3支的患者cd62p、Hcy及hs-CRP水平显著高于病变1支的患者(P<0.05)。病变数3支的患者cd62p、Hcy及hs-CRP水平显著高于2支的患者(P<0.05)。cd62p、Hcy和hs-CRP与Gensini评分呈显著正相关(P<0.05)。结论:cd62p、Hcy及hs-CRP与AMI患者冠状动脉病变程度呈显著正相关,可以通过对cd62p、Hcy及hs-CRP水平的检测了解AMI患者冠状动脉病变程度。

Objective:To investigate the correlation between cd42b,cd62p,homocysteine(Hcy)and highsensitivity C-reactive protein(hs-CRP)and severity of coronary artery disease in patients with acute myocardial infarction(AMI).Methods:Totally 154 patients with AMI were enrolled.According to the Gensini score,they were divided as L group(≤55 points),M group(56-84 points)and H group(85-172 points).The differences in levels of cd42b,cd62p,Hcy and hs-CRP were compared between the three groups.The differences in cd42b,cd62p,Hcy and hs-CRP levels were compared between patients with different coronary lesions.The correlation between cd42b,cd62p,Hcy and hs-CRP and the extent of coronary lesions was analyzed.Results:The levels of cd62p,Hcy and hs-CRP were significantly different between groups(P<0.05).The cd62p,Hcy and hs-CRP levels in group M were significantly higher than those in group L(P<0.05).The levels of cd62p,Hcy,hs-CRP and hs-CRP were significantly higher in group H than those of L and M groups(P<0.05).There was no significant difference in cd42b levels between groups.The levels of cd62p,Hcy and hs-CRP in different lesions were significantly different(P<0.05).The levels of cd62p,Hcy and hs-CRP in patients with 2 and 3 lesions were significantly higher than those with 1 lesion(P<0.05).The levels of cd62p,Hcy and hs-CRP in patients with 3 lesions were significantly higher than those with 2 lesions(P<0.05).With the increase of Gensini score,cd42b showed a downward trend,with group L the highest level of cd42b,and group H the lowest level of cd42b.There was a significant positive correlation between cd62p,Hcy and hs-CRP and Gensini score(P<0.05).Conclusion:cd62p,Hcy and hs-CRP are significantly positively correlated with the degree of coronary artery lesions in patients with AMI,suggesting the detection of cd62p,Hcy and hs-CRP levels could be used to understand the degree of coronary artery lesions in AMI patients.