地特胰岛素联合阿托伐他汀和丹参注射液治疗2型糖尿病下肢血管病变中对血流动力学、D-二聚体的影响

Effects of insulin detemir combined with atorvastatin and salvia injection on hemodynamics and D-dimer of patients with type 2 diabetes mellitus with lower extremity arterial disease

目的探讨地特胰岛素联合阿托伐他汀和丹参注射液治疗2型糖尿病下肢血管病变中对血流动力学、D-二聚体的影响。方法选择2017年1~6月在医院内分泌科住院的2型糖尿病下肢血管病变患者120例为研究对象,随机分为他汀组、丹参组以及联合组各40例。他汀组采用地特胰岛素联合阿托伐他汀治疗,丹参组采用地特胰岛素联合丹参注射液治疗,联合组采用地特胰岛素联合阿托伐他汀、丹参注射液治疗。比较治疗前后三组血糖、血脂、D-二聚体、ABI、TBI水平以及临床疗效。结果联合组总有效率显著高于他汀组与丹参组,差异有统计学意义(P<0.05)。治疗后,联合组ABI、TBI显著高于他汀组与丹参组治疗后,差异有统计学意义(P<0.05)。治疗后,联合组TC、TG、LDL-C水平显著低于他汀组与丹参组,HDL-C显著高于他汀组与丹参组,差异有统计学意义(P<0.05)。治疗后联合组D-二聚体水平显著低于他汀组与丹参组,差异有统计学意义(P<0.05)。结论地特胰岛素联合阿托伐他汀和丹参注射液治疗2型糖尿病下肢血管病变能显著改善D-二聚体水平,改善ABI、TBI水平,提高临床疗效。

Objective To explore effects of insulin detemir combined with atorvastatin and Salvia injection on hemodynamics and D-dimer of patients with type 2 diabetes mellitus with lower extremity arterial disease.Methods 120 patients with type 2 diabetes mellitus with lower extremity arterial disease who were hospitalized in department of endocrinology in the hospital from January to June 2017 were selected as research objects.They were randomly divided into statin group,Salvia group and combination group,with 40 cases in every group.The statin group was treated with insulin detemir combined with atorvastatin,the salvia group was treated with insulin detemir combined with Salvia injection while the combined group was treated with insulin detemir combined with atorvastatin and Salvia injection.The levels of blood sugar,blood lipid,D-dimer,ABI,TBI and clinical curative effects were compared before and after treatment.Results The total effective rate of the combined group was significantly higher than that of statin group and Salvia group,and the difference was statistically significant(P<0.05).After treatment,ABI and TBI in combined group were significantly higher than those in statin group and Salvia group,and the difference was statistically significant(P<0.05).After treatment,the levels of TC,TG and LDL-C in combined group were significantly lower than those in statin group and Salvia group,and HDL-C was significantly higher than those in statin group and Salvia group.The difference was statistically significant(P<0.05).After treatment,D-dimer level in combined group was significantly lower than that in statin group and Salvia group,and the difference was statistically significant(P<0.05).Conclusion Dexter insulin combined with atorvastatin and Salvia injection in the treatment of lower extremity vascular disease of patients with type 2 diabetes mellitus can significantly decrease D-dimer levels,improve ABI and TBI levels and improve clinical curative effects.