氨溴索联用珂立苏对早产儿呼吸窘迫综合征疗效及血气指标影响

Effect of ambroxol combined with kelisu on neonatal respiratory distress syndrome and blood gas index

目的研究氨溴索联用珂立苏对早产儿呼吸窘迫综合征(NRDS)疗效及血气指标影响。方法选取我院于2017年1月~2019年2月收治的122例NRDS患儿,采取随机数字表法将其分为观察组(61例)和对照组(61例)。对照组患儿在常规治疗的基础上给予珂立苏,观察组患儿在对照组患儿的基础上加用氨溴索,比较两组患儿的临床疗效以及治疗前后的血气分析指标和炎症反应指标。结果观察组总有效率为96.72%,明显高于对照组的83.61%(P<0.05);治疗后,观察组的PaO 2和pH较对照组明显提高(P<0.05),PaCO2较对照组明显下降(P<0.05),炎症反应指标下降水平较对照组更明显(P<0.05)。结论氨溴索联用珂立苏的方法较单用珂立苏对NRDS患儿有明显的治疗效果,可有效改善血气指标化和炎症反应,值得推广应用。

Objective To study the effect of ambroxol combined with kelisu on neonatal respiratory distress syndrome(NRDS)and blood gas index.Methods A total of 122 children with NRDS treated in our hospital between January 2017 and February 2019 were selected and divided into observation group(n=61)and control group(n=61)using random number table method.The children in the control group were given kelisu on the basis of conventional treatment.The children in the observation group were given ambroxol on the basis of the control group.The clinical efficacy,the blood gas index and inflammation response before and after treatment were compared between the two groups.Results The total effective rate in the observation group(96.721%)was significantly higher than that in the control group(83.607%)(P<0.05).After treatment,arterial partial pressure of oxygen(PaO2)and pH in the observation group were significantly higher than those in the control group(P<0.05),while the arterial partial pressure of carbon dioxide(PaCO2)decreased significantly(P<0.05),and the level of inflammatory response indicators decreased more significantly(P<0.05).Conclusion The method of ambroxol combined with kelisu has more remarkable effect on children with NRDS as compared with kelisu alone.It can effectively improve blood gas index and inflammatory response,and it is worth popularizing.