参附注射液对感染性休克患者脏器功能的保护及改善预后的作用

Role of ginseng-monkshood extract injection in protection of organ function and prognosis improvement in patients with septic shock

目的评定参附注射液针对感染性休克患者脏器功能的临床保护及改善效果。方法本院2015年3月~2019年3月诊断为感染性休克的患者80例,根据其选择的治疗方案分成对照组和研究组,每组各40例。对照组采取常规的抗感染治疗和抗休克治疗,如补给血容量,纠正酸中毒,调节血管收缩功能,液体复苏及去甲肾上腺素升压,尽早使用抗生素等;研究组在对照组基础上加入参附注射液静脉注射治疗。观察两组患者的基本检测指标(血压,排尿,精神状况,血管收缩情况等)改善情况及记录对比血流动量学检测指标包括心脏指数(CI),胸腔内血容量指数(ITBVI),系统血管阻力指数(SVRI)及血乳酸(Lac)等及治疗前(T0)和治疗后24h(T1),48h(T2),72h(T3)的肝肾功能指标(包括AST,ALT,TBA,BUN,Cr)。结果在感染性休克治疗后研究组的CI,ITBVI,SVRI指标较对照组明显增高且肝肾功能水平也明显提高,差异有统计学意义(P<0.05);治疗后治疗组血乳糖较对照组指标明显下降,差异有统计学意义(P<0.05),研究组患者的基本检测指标恢复情况也强于对照组。结论参附注射液的使用在治疗感染性休克中临床效果明显,能显著改善肝肾功能障碍及调节患者基本指标和血流动量指标。

Objective To evaluate clinical protection of organ function and improvement effect of Ginsengmonkshood extract injection for patients with septic shock.Methods 80 patients who were diagnosed as septic shock in our hospital from March 2015 to March 2019 were selected.According to different treatment regimens,they were divided into the control group and the study group,with 40 cases in each group.The control group was given routine anti-infective treatment and anti-shock treatment,such as replenishing blood volume,correcting acidosis,regulating vasoconstriction,fluid resuscitation,norepinephrine boost and using antibiotics as early as possible.The study group was treated with Ginseng-monkshood extract injection n basis of the control group.The improvement of basic test indexes(blood pressure,urination,mental status,vasoconstriction,etc.)was observed.Hemodynamic indexes including cardiac index(CI),intrathoracic blood volume index(ITBVI),systemic vascular resistance index(SVRI)and blood lactate(Lac)and liver and kidney function indexes(including AST,ALT,TBA,BUN,Cr)before treatment(T0)and 24h(T1),48h(T2),72h(T3)after treatment were recorded and compared.Results After treatment of septic shock,CI,ITBVI,and SVRI indexes of the study group were significantly higher than those of the control group and the liver and kidney function levels were also significantly improved.The difference was statistically significant(P<0.05).After treatment,the blood lactose in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The recovery of basic test indexes in the study group was also stronger than that in the control group.Conclusion Ginseng-monkshood extract injection in treatment of patients with septic shock has significant clinical curative effects,which can significantly improve liver and kidney dysfunction and regulate the patients’basic indexes and hemodynamic indexes.