经鼻持续气道正压通气与经鼻导管高流量通气对早产儿呼吸窘迫综合征的临床疗效对比

Comparison of clinical curative effects of nasal continuous positive airway pressure ventilation and humidified high flow nasal cannula in treatment of neonatal respiratory distress syndrome

目的对比早产儿呼吸窘迫综合征(NRDS)实施经鼻持续气道正压通气(NCPAP)与经鼻导管高流量通气(HHFNC)的临床疗效。方法选取2017年6月~2018年12月我院收治的94例NRDS新生儿为观察对象。按随机数字表法分为观察组与对照组各47例,两组均实施常规治疗,在此基础上对照组予以NCPAP,观察组则予以HHFNC治疗。对比两组疗效,并发症及血气分析指标。结果观察组的总有效率为95.74%,明显高于对照组的82.98%(P<0.05)。观察组的并发症总发生率为8.51%,明显低于对照组的23.40%(P<0.05)。两组治疗前、治疗6h后、12h后的血气分析指标相比差异无统计学意义(P>0.05)。两组治疗6h后、12h后的血氧分压(PaO2)、PH值水平明显高于治疗前,而血二氧化碳分压(PaCO2)水平明显低于治疗前(P<0.05)。结论HHFNC治疗的NRDS患儿疗效更好,安全性也更佳,对患儿血气指标的影响较小。

Objective To compare clinical curative effects of nasal continuous positive airway pressure(NCPAP)ventilation and humidified high flow nasal cannula(HHFNC)in treatment of neonatal respiratory distress syndrome.Methods 94 neonates with NRDS who were admitted and treated in our hospital from June 2017 to December 2018 were selected as the research objects.According to random number table method,they were divided into the observation group and the control group,with 47 cases in each group.The two groups were treated with routine therapy.The control group was treated with NCPAP on this basis while the observation group was treated with HHFNC.The curative effects,complications and blood gas analysis were compared between the two groups.Results The total effective rate of the observation group was 95.74%,which was significantly higher than 82.98%of the control group(P<0.05).The total incidence of complications in the observation group was 8.51%,which was significantly lower than 23.40%in the control group of(P<0.05).There was no statistically significant difference in blood gas analysis between the two groups before treatment,6 hours after treatment and 12 hours after treatment(P>0.05).The levels of blood oxygen partial pressure(PaO2)and PH values of 6 hours and 12 hours after treatment in the two groups were significantly higher than those before treatment,while the level of blood carbon dioxide partial pressure(PaCO2)was significantly lower than that before treatment(P<0.05).Conclusion HHFNC in treatment of NRDS has better curative effects and safety,which has little effect on blood gas index.