锥虫蛋白磷酸酶研究进展

Progress on Protein Phosphatase in Trypanosomes

蛋白质磷酸化修饰是生物体内最普遍、最重要的翻译后修饰方式之一,被描述为细胞生理活动的“分子开关”。蛋白质的磷酸化和去磷酸化是受蛋白激酶和蛋白磷酸酶共同调控的动态生物过程,通过改变蛋白质构象从而改变蛋白质的功能,在细胞信号转导中起重要作用。论文在已有的研究基础上,综述了锥虫的磷酸化蛋白质组学以及蛋白磷酸酶的研究进展,对深入研究蛋白质翻译后修饰的功能具有重要意义。

Phosphorylation is one of the most common and critical post-translational modifications in organisms and is described as a"molecular switch"of cellular physiological activities.Phosphorylation and dephosphorylation are dynamic biological processes co-regulated by protein kinase and protein phosphatase,which change protein function by changing protein conformation and play an important role in cell signal transduction.On the basis of the previous studies,the research progress on phosphoproteome and protein phosphatase in trypanosomes were reviewed,which is of great significance to further study the function of post-translational modifications.