摘要
MAPK信号通路是由丝/苏氨酸蛋白激酶组成的蛋白激酶系统,包括ERK1/2、JNKs、p38MAPK和ERK5,在细胞的病理、生理过程中均发挥重要作用。HBV感染宿主肝细胞后,可以通过MAPK信号通路上调细胞周期蛋白、基质金属蛋白酶、炎症因子的表达和HBV复制等,进而促进HBV感染相关性HCC的增殖、侵袭和迁移。现就MAPK信号通路与HBV感染相关性HCC增殖、侵袭和迁移的机制作一概述。
MAPK signaling pathway is a protein kinase system composed of serine/threonine protein kinases,including ERK1/2,JNKs,p38MAPK and ERK5.It plays an important role in the pathological and physiological processes of cells.After HBV infects host hepatocytes,the expression of cyclin,matrix metalloproteinase,inflammatory factors and HBV replication can be regulated through the MAPK signaling pathway to promote the proliferation,invasion and migration of HBV related HCC.This article reviews the mechanism of proliferation,invasion and migration of HBV related HCC through MAPK signaling pathway.
作者
杨晓娟
朱博兰
张裕
卢利霞
惠玲
于晓辉
任小龙
YANG Xiaojuan;ZHU Bolan;ZHANG Yu;LU Lixia;HUI Ling;YU Xiaohui;REN Xiaolong(Gansu University of Chinese Medicine,Lanzhou 730000;Department of Gastroenterology,the 940th Hospital of Joint Logistics Support Force of PLA;Lab of Stem Cells and Gene Drugs of Gansu Province,China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第11期1303-1307,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
甘肃中医药大学研究生创新基金项目(2019CX34)
兰州市科技发展计划项目(2015-2-68)
甘肃省科技支撑计划项目(1604FKCA101)
