肿瘤坏死因子-α对细胞生存状态的调控及其与眼科疾病的关系

Regulation of TNF-αon cell survival conditions and its relationship with ophthalmological disorders

肿瘤坏死因子(TNF)-α是炎症应答中的关键分子,对细胞的存活与死亡发挥着重要的调控作用。TNF-α可能参与多种炎性疾病的发病过程,抑制TNF-α可显著改善许多疾病的临床表现。本文介绍了TNF-α及其受体的结构、功能特点以及相互作用,阐述了TNF-α在不同生理状态下对细胞存活、凋亡与程序性坏死的调控机制,并结合最新的临床与基础研究结果,初步分析了TNF-α与眼科常见病变,如视网膜及角膜的炎症反应、脉络膜新生血管等之间的联系以及TNF-α单克隆抗体英夫利昔的临床应用和治疗效果,从而为未来眼科炎症疾病的治疗以及科学研究提供借鉴。

Tumor necrosis factor-α(TNF-α)is a key molecule of the inflammatory response,and plays a significant role in regulating cell survival and death.Many studies demonstrate that TNF-αmay be implicated in the pathogenesis of various inflammatory conditions.Inhibiting the activity of TNF-αcan dramatically improve the manifestations of many diseases.This review introduced the structural and functional characters of TNF-αand its receptors,and then summarized the regulating mechanisms TNF-αon cell survival、apoptosis and necroptosis.Besides,combining with the newly achievements of clinical and fundamental researches,this review analyzed the connections between TNF-αand common disorders in ophthalmology,such as the inflammation of retina and cornea,choroidal neovascularization,and summarized the clinical application and efficacy of infliximab,TNF-αmonoclonal antibody.This review may provide references for the treatment of inflammatory diseases in ophthalmology and scientific researches in the future.