白头翁加味汤治疗溃疡性结肠炎的作用研究

Clinical Study on the Inflammatory Factors in Ulcerative Colitis with Pulsatilla Plus Decoctions

目的:观察白头翁加味汤治疗溃疡性结肠炎(UC)的临床有效性、安全性及评估4种炎症因子的临床监测意义。方法:将入选的78例UC患者随机分为两组:对照组和试验组,各39例。对照组采用柳氮磺胺吡啶片常规治疗;试验组采用白头翁加味汤灌肠治疗。两组均以一个月为一疗程,连续观察两个疗程。比较两组有效率、安全性及其治疗前后血清中MDA浓度、SOD活力、IL-4和COX-2含量。结果:试验组、对照组总有效率分别为94.9%、79.5%,试验组明显>对照组,具有统计学意义(P<0.05)。试验组治疗前后相比,血清MDA浓度和COX-2浓度均显著下降,SOD活性和IL-4含量均明显升高,具有统计学意义(P<0.05);治疗后试验组与对照组相比,血清MDA和COX-2浓度均显著下降,SOD活性和IL-4含量均明显升高,具有统计学意义(P<0.05)。结论:应用白头翁加味汤治疗UC,血清MDA浓度、SOD活力、IL-4和COX-2含量均明显改变,可用于临床指标监测,且其疗效优于对照组,安全性高,不良反应少。

Objective:To observe the clinical efficacy and safety of Pulsatillae Plus Decoctions in the treatment of ulcerative colitis,and evaluate the clinical monitoring significance of four inflammatory factors.Methods:Seventy-eight patients with ulcerative colitis were randomly divided into the control group and the experimental group with 39 cases in each.Patients in the control group were treated with sulfasalazine tablets.Those in the experimental group were treated with Pulsatilla Plus Decoctions.Patients in the two groups were treated for one course a month,and were observed for two courses continuously.The efficiency and safety of the two treatments were compared,and the serum MDA concentrations,SOD activities,IL-4 and COX-2 levels before and after treatment were compared.Results:The total effective rates of the experimental group and the control group were 94.9%and 79.5%,respectively(P<0.05).After treatments,the concentrations of serum MDA and COX-2 were significantly decreased,while the SOD activities and IL-4 contents were significantly increased(P<0.05),and these effects were more significant in the experimental group than in the control group(P<0.05).Conclusion:After treatment of UC with Pulsatilla Plus Decoctions,serum MDA concentrations,SOD activities,IL-4 and COX-2 levels were significantly changed,which can be used for clinical monitoring,and its curative effects are better than those of the control group,with high safety and few adverse reactions.