肺表面活性物质联合CPAP治疗NRDS的疗效

Efficacy of Pulmonary Surfactant Combined with CPAP in the Treatment of Neonatal Respiratory Distress Syndrome

目的观察肺表面活性物质(PS)联合持续气道正压通气(CPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法选择2016年6月~2019年5月我院收治的62例NRDS患儿,按随机数字表法分为对照组和观察组,各31例。对照组接受CPAP治疗,观察组在对照组基础上联合PS治疗。比较两组临床疗效、pH、动脉二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、氧合指数(OI)、住院时间及并发症发生情况。结果观察组总有效率为93.55%,高于对照组的74.19%,差异有统计学意义(P<0.05);观察组pH、PaO2、OI均高于对照组,PaCO2低于对照组,差异均有统计学意义(P<0.05);观察组支气管肺发育不良发生率低于对照组,差异有统计学意义(P<0.05);两组肺不张、气胸及腹胀发生率比较,差异无统计学意义(P>0.05);观察组住院时间短于对照组,差异有统计学意义(P<0.05)。结论NRDS患儿接受PS联合CPAP治疗有利于改善动脉血气指标,提升呼吸功能,缩短住院时间,降低相关并发症发生率。

Objective To observe the effect of pulmonary surfactant(PS)combined with continuous positive airway pressure(CPAP)on neonatal respiratory distress syndrome(NRDS).Methods 62 children with NRDS admitted in our hospital from June 2016 to May 2019 were divided into control group and observation group according to the random number table method,with 31 cases each.The control group received CPAP treatment,and the observation group combined with PS treatment on the basis of the control group.The clinical efficacy,pH,partial arterial carbon dioxide pressure(PaCO2),partial arterial oxygen pressure(PaO2),oxygenation index(OI),length of hospital stay,and complications were compared between the two groups.Results The total effective rate in the observation group was 93.55%,which was higher than 74.19%in the control group,the differences were statistically significant(P<0.05).The pH,PaO2,and OI in the observation group were higher than the control group,PaCO2 was lower than the control group,the differences were statistically significant(P<0.05);The incidence of bronchopulmonary dysplasia in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of atelectasis,pneumothorax,and abdominal distension in the two groups(P>0.05).The length of hospital stay was shorter than that of the control group,the difference was statistically significant(P<0.05).Conclusion Children with NRDS receiving PS combined with CPAP can improve arterial blood gas parameters,improve respiratory function,shorten hospital stay,and reduce the incidence of related complications.