奥拉西坦和吡拉西坦治疗老年脑出血后认知功能障碍的疗效比较

Efficacy Comparison of the Oxiracetam and Piracetam in the Treatment of Cognitive Impairment in Elderly Patients with Cerebral Hemorrhage

目的比较奥拉西坦和吡拉西坦治疗老年脑出血后认知功能障碍的疗效。方法选择2018年2月~2019年2月我院诊治老年脑出血后认知功能障碍患者116例,随机分为对照组和观察组,各58例。对照组采用吡拉西坦治疗,观察组采用奥拉西坦治疗,比较两组治疗前后蒙特利尔认知评估(MoCA)量表、简易智能精神状态检查(MMSE)量表、日常生活活动(ADL)量评分以及临床不良反应。结果治疗后两组MoCA、MMSE评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后两组ADL评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.34%,与对照组的12.07%比较,差异无统计学意义(P>0.05)。结论奥拉西坦可更好的改善脑出血患者认知功能障碍,提高患者日常生活能力,且临床不良反应少,临床应用效果确切。

Objective To compare the efficacy of oxiracetam and piracetam in the treatment of cognitive impairment in elderly patients with cerebral hemorrhage.Methods From February 2018 to February 2019,116 elderly patients with cognitive impairment after cerebral hemorrhage were diagnosed and treated in our hospital.They were randomly divided into the control group and the observation group,with 58 cases in each group.The control group was treated with piracetam,and the observation group was treated with oxiracetam.The Montreal Cognitive Assessment(MoCA)scale,the Simple Intelligent Mental State Examination(MMSE)scale,and the activities of daily living(ADL)were compared between the two groups.Quantitative scores and clinical adverse reactions.Results After treatment,the MoCA and MMSE scores of the two groups were higher than before the treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).After treatment,the ADL scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 10.34%,compared with 12.07%in the control group,the difference was not statistically significant(P>0.05).Conclusion Oxiracetam can better improve cognitive dysfunction in patients with intracerebral hemorrhage,improve patients'ability of daily living,and has fewer clinical adverse reactions,and the clinical application effect is definite.