阴道放置米索前列醇在终止6～10周妊娠负压吸宫术前的应用

Application of Vaginal Misoprostol Before Termination of Negative Pressure Uterine Aspiration with 6 to 10 Weeks

目的探讨米索前列醇在终止6~10周妊娠负压吸宫术前的应用效果。方法选取2018年5月~2019年5月我院收治的终止6~10周妊娠患者129例,按照随机数字表法分为对照1组、对照2组和研究组,每组43例。对照1组术前不使用药物干预,对照2组术前口服米索前列醇片联合米非司酮进行干预,研究组术前3 h阴道放置米索前列醇干预,比较三组宫颈软化程度、手术情况、出血量、人流综合征、术后疼痛、宫颈粘连及感染发生情况。结果研究组宫颈软化有效率高于对照1组、对照2组(P<0.05);对照2组宫颈软化有效率高于对照1组(P<0.05);研究组手术时间、出血量、疼痛以及人流综合征发生低于对照1组、对照2组,且对照2组低于对照1组(P<0.05);研究组并发症发生率低于对照1组、对照2组,且对照2组并发症发生率低于对照组1组(P<0.05)。结论对于接受负压吸宫术治疗的妊娠10周内患者,术前3 h阴道置入米索前列醇进行治疗,可以有效提高患者宫颈软化效果,缩短手术时间,减少出血量,降低术后疼痛以及人流综合征的发生,提高负压吸宫术的治疗安全性,可在临床中进一步应用。

Objective To investigate the effect of misoprostol before termination of negative pressure uterine aspiration at 6-10 weeks of pregnancy.Methods From May 2018 to May 2019,129 patients with termination of 6-10 weeks of pregnancy admitted to our hospital were selected and divided into control group 1,control group 2 and study group according to the random number table method,with 43 patients in each group.The control group 1 did not use drug intervention before operation,the control group 2 took oral misoprostol tablets combined with mifepristone before intervention,and the study group intervened by placing misoprostol in the vagina 3 h before surgery.Surgery,bleeding volume,abortion syndrome,postoperative pain,cervical adhesions and infections.Results The effective rate of cervical softening in the study group was higher than that in the control group 1 and control group 2(P<0.05);the effective rate of cervical softening in the control group 2 was higher than that in the control group 1(P<0.05);the surgical time,bleeding volume,pain,and abortion syndrome in the study group were lower than those in the control group 1,control group 2,and the control group 2 were lower than the control group 1(P<0.05);the complication rate of the study group was lower than that of the control group 1 and control group 2,and the complication rate of the control group 2 was lower than that of the control group 1(P<0.05).Conclusion For pregnant women who have received negative pressure aspiration surgery within 10 weeks of pregnancy,vaginal misoprostol treatment 3 h before surgery can effectively improve the cervical softening effect,shorten the operation time,reduce bleeding volume,and reduce postoperative pain As well as the occurrence of abortion syndrome,improving the safety of negative pressure aspiration surgery can be further applied in the clinic.