标准四联疗法与序贯疗法应用于Hp阳性胃溃疡患者中的效果研究

Study on the Efficacy of Standard Quadruple Therapy and Sequential Therapy in Patients with Hp Positive Gastric Ulcer

目的比较标准四联疗法与序贯疗法应用于幽门螺杆菌(Hp)阳性胃溃疡患者中的效果。方法选择2018年1月-2018年12月河南大学医院收治的Hp阳性胃溃疡患者96例,以掷骰子法进行分组,其中对照组与研究组各纳入患者48例。对照组患者接受标准四联疗法治疗,研究组患者接受序贯疗法治疗。比较两组溃疡愈合的总有效率、Hp根除率,以及药物不良反应情况。结果研究组溃疡愈合的总有效率高于对照组(P<0.05)。研究组Hp根除率为93.75%,高于对照组77.08%(P<0.05)。研究组治疗期间不良反应发生率6.25%与对照组8.33%对比差异无统计学意义(P>0.05)。结论与标准四联疗法相比,序贯疗法能够有效促进Hp阳性胃溃疡患者溃疡面的愈合效果,提高Hp根除率,值得临床应用。

Objective To compare the effect of standard quadruple therapy with sequential therapy in patients with helicobacter pylori(Hp)positive gastric ulcer.Methods 96 patients with Hp positive gastric ulcer admitted to Henan University Hospital from January 2018 to December 2018 were selected and divided into the control group and the research group by dice method,48 cases in each group.The control group received standard quadruple therapy,however,the study group received sequential therapy.The total effective rate of ulcer healing,eradication rate of Hp,and adverse drug reactions were compared between the two groups.Results The total effective rate of ulcer healing in the study group was higher than that in the control group(P<0.05).The eradication rate of Hp in the study group(93.75%)was higher than the control group(77.08%)(P<0.05).There was no statistically significant difference in the incidence of adverse reactions(6.25%)between the two groups(8.33%)(P>0.05).Conclusion Compared with standard quadruple therapy,sequential therapy can effectively promote the healing effect of ulcer surface in patients with Hp positive gastric ulcer and improve the eradication rate of Hp,which is worthy of clinical application.