加味生化汤合宫外孕1号方治疗稽留流产的疗效观察

Observation on Efficacy of Modified Shenghua Decoction Combined with No.1 Prescription for Ectopic Pregnancy in Treatment of Missed Abortion

目的:探讨加味生化汤合宫外孕1号方治疗稽留流产的临床疗效.方法:选取2016年2月至2018年10月湖北医药学院附属随州医院收治的血瘀型稽留流产患者110例,按随机数字表法分为治疗组和对照组,每组55例.对照组患者给予米非司酮联合米索前列醇治疗,治疗组患者在对照组的基础上加用加味生化汤合宫外孕1号方治疗.观察两组患者的流产情况、阴道流血量及流血时间、服药后排胎时间、子宫开始收缩时间、激素水平[β-人绒毛膜促性腺素(β-HCG)、孕酮(P)和雌二醇(E2)]及不良反应发生情况.结果:治疗组患者的完全流产率明显高于对照组,差异有统计学意义(P<0.05).治疗组患者阴道流血量明显低于对照组,阴道流血时间、服药后排胎时间及子宫开始收缩时间明显短于对照组,差异均有统计学意义(P<0.05).治疗后,两组患者血清β-HCG、P及E2水平较治疗前明显降低,且治疗组患者明显低于对照组,差异均有统计学意义(P<0.05).治疗期间,治疗组患者的不良反应发生率为9.09%(5/55),明显低于对照组的25.45%(14/55),差异有统计学意义(P<0.05).结论:加味生化汤合宫外孕1号方治疗稽留流产的疗效确切,可有效提高完全流产率,促进孕囊排出,且明显缩短阴道出血时间,减少出血量,安全性较高.

OBJECTIVE:To probe into the clinical efficacy of modified Shenghua decoction combined with No.1 prescription for ectopic pregnancy in treatment of missed abortion.METHODS:110 patients with missed abortion of blood stasis type admitted into the Affiliated Suizhou Hospital of Hubei Medical College from Feb.2016 to Oct.2018 were selected and divided into treatment group and control group via random number,with 55 cases in each group.The control group was give mifepristone combined with misoprostol,the observation group was given modified Shenghua decoction combined with No.1 prescription for ectopic pregnancy based on the control group.The incidences of abortion,vaginal bleeding amount and bleeding duration,time for abortion after taking medicine,uterine contraction time,hormone levels[β-human chorionic gonadotropin(β-HCG),progesterone(P)and estradiol(E 2)]and incidences of adverse reactions of the two groups were observed.RESULTS:The complete abortion rate of treatment group was significantly higher than that of the control group,with statistically significant difference(P<0.05).The vaginal bleeding amount of treatment group was significantly lower than that of the control group,while the vaginal bleeding duration,time for abortion after taking medicine and uterine contraction time of treatment group were significantly shorter than those of the control group,with statistically significant differences(P<0.05).After treatment,the serumβ-HCG,P and E 2 levels of both groups had been significantly decreased,and those of the treatment group were significantly lower than the control group,with statistically significant differences(P<0.05).During treatment,the incidences of adverse drug reactions of treatment group was 9.09%(5/55),which was significantly lower than that of the control group(25.45%,14/55),with statistically significant difference(P<0.05).CONCLUSIONS:The efficacy of modified Shenghua decoction combined with No.1 prescription for ectopic pregnancy in treatment of missed abortion is remarkable,which can effectively improve the complete abortion rate,promote excretion of fertilized egg,shorten the duration of vaginal bleeding and reduce the bleeding amount,with high safety.