盆炎舒方联合盐酸克林霉素对急性盆腔炎患者TGF-β1、IL-18和CRP的影响

Effects of Penyanshu Prescription Combined with Clindamycin Hydrochloride on TGF-β1, IL-18 and CRP in APID Patients

目的:探讨盆炎舒方联合盐酸克林霉素对急性盆腔炎(acute pelvic infcammatory disease,APID)患者血清转化生长因子β1(TGF-β1)、白细胞介素18(IL-18)和C-反应蛋白(CRP)的影响。方法:将APID患者136例随机分为研究组和对照组各68例,2组均给予常规治疗,对照组在此基础上采用盐酸克林霉素治疗,研究组在对照组基础上加用盆炎舒方治疗。观察2组患者中医症候积分、炎性包块和盆腔积液变化情况及临床疗效,同时观察血液流变学和血清TGF-β1、IL-18、CRP水平。结果:治疗后2组患者中医症候积分低于治疗前(P<0.05),且研究组低于对照组(P<0.05);治疗后2组患者炎性包块直径小于治疗前(P<0.01),且研究组小于对照组(P<0.01);同时盆腔积液深度低于治疗前(P<0.01),且研究组低于对照组(P<0.01);研究组总有效率为91.2%,高于对照组的77.9%(P<0.05);治疗后2组患者全血黏度高切值、低切值及红细胞聚集指数、血浆黏度低于治疗前(P<0.05),且研究组低于对照组(P<0.05);治疗后2组患者IL-18、CRP水平低于治疗前(P<0.05),且研究组低于对照组(P<0.05),2组患者TGF-β1水平高于治疗前(P<0.05),且研究组高于对照组(P<0.05)。结论:盆炎舒方联合盐酸克林霉素可有效改善APID患者临床症状、血液流变学和血清TGF-β1、IL-18、CRP水平,提高治疗效果。

Objective:To discuss the effects of Penyanshu prescription joined with clindamycin hydrochloride on TGF-β1,IL-18 and CRP of the patients with acute pelvic inflammatory disease(APID).Methods:All 136 APID patients were randomized into the study group and the control group,68 cases each group,both groups accepted conventional therapy,the control group adopted clindamycin hydrochloride,and the study group were given Penyanshu prescription.To observe TCM syndrome scores,inflammatory lump,pelvic effusion and clinical effects between both groups,simultaneously,to detect the levels of hemorheology,the levels of TGF-β1,IL-18 and CRP.Results:After treating,TCM syndrome scores of both groups were lower than these before treating(P<0.05),and the study group was lower than the control group(P<0.05);inflammatory lumps diameter of both groups after treating were lower than these before treating(P<0.05),and the study group was lower than the control group(P<0.05);pelvic effusion depth of both groups after treating were lower than these before treating(P<0.05),and the study group was lower than the control group(P<0.05);Total effective rate of the study group was 91.2%,higher than 77.9%of the control group(P<0.05);after treating,high-shear value of whole blood viscosity,low-shear value,erythrocyte aggregation index,plasma viscosity of both groups after treating were lower than these before treating(P<0.05),and the study group was lower than the control group(P<0.05);after treating,the levels of IL-18 and CRP of both groups were lower than these before treating(P<0.05),and the study group was lower than the control group(P<0.05),the levels of TGF-β1 in both groups were higher than these before treating(P<0.05),and the study group was higher than the control group(P<0.05).Conclusion:Penyanshu prescription joined with clindamycin hydrochloride could effectively improve clinical symptoms of the patients,hemorheology,the levels of TGF-β1,IL-18 and CRP,and raise therapeutic effects.