FK409类NO供体型他汀衍生物合成及活性评价

Synthesis and activity assay of novel FK409 NO-donating statin derivatives

目的合成系列FK409类NO供体型他汀衍生物并进行体外活性评价。方法本文选用FK409类NO供体与阿托伐他汀、匹伐他汀及瑞舒伐他汀3种他汀药物分别通过酯化进行偶联。结果设计合成了2个FK409类NO供体和6个该类NO供体型他汀衍生物。结论通过体外活性测定,目标化合物具有良好的NO释放活性。

Objective To synthesize a series of novel FK409 NO-donating statin derivatives and evaluate their NO release activities in vitro.Methods In this study,we used esterification reaction to couple FK409 NO-donors and three statins,respectively.Results Two FK409 NO-donors and six FK409 NO-donating statin derivatives were designed and synthesized.Conclusion The target compounds showed good NO release activity in vitro.