血清前清蛋白联合人附睾上皮分泌蛋白4检测在卵巢良恶性疾病鉴别中的应用价值

Application value of prealbumin and human epididymis secretory protein 4 detection in the differential diagnosis of benign and malignant ovarian disease

目的探析卵巢良恶性疾病应用人附睾上皮分泌蛋白4(HE4)和血清前清蛋白(PA)联合检测的鉴别价值。方法选择2017年7月-2018年4月在我院接受诊治的卵巢病变患者90例,均进行病理检查,以病理检查结果为标准,分为卵巢恶性疾病组(n=40)、卵巢良性疾病组(n=50),选择同期体检健康人群46例为健康对照组,分别检测各组的HE4、PA水平。结果卵巢恶性疾病组的HE4水平显著高于卵巢良性疾病组、健康对照组,差异有统计学意义(P<0.05);卵巢恶性疾病组的PA水平显著低于卵巢良性疾病组、健康对照组,差异有统计学意义(P<0.05)。卵巢良性疾病组HE4水平显著高于健康对照组,PA水平显著低于健康对照组,差异有统计学意义(P<0.05)。同时检测HE4、PA的准确性显著高于单独一项指标检测,差异有统计学意义(P<0.05),单独一项指标检测的准确性差异无统计学意义(P>0.05)。结论人附睾上皮分泌蛋白4和血清前清蛋白可作为鉴别卵巢疾病性质的有效指标,且联合检测的准确性更高。

Objective To discuss the application value of human epididymis secretory protein 4(HE4)and prealbumin(PA)detection in the differential diagnosis of benign and malignant ovarian disease. Methods 90 ovarian disease patients checked from July 2017 to April 2018 in our hospital were selected. The pathological examination results were seen as golden standard. Patients were assigned to malignant group(n=40)and benign group(n=50)according to disease nature;46 healthy check-ups were selected as control group. HE4 and PA contents were detected and compared.The diagnosis accuracy based on single indicator and combined examination was compared. Results HE4 contents in malignant group were higher than benign group and control group,with statistically significant difference(P<0.05). PA contents in malignant group were lower than benign group and control group,with statistically significant difference(P<0.05). HE contents in benign group were higher than control group while PA contents were lower than control group(P<0.05).The diagnosis accuracy based on HE4 and PA examination was higher than single examination(P<0.05);the diagnosis accuracy based on HE4 or PA showed no statistically significant difference(P>0.05).Conclusion The combination of HE4 and PA can make the differential diagnosis of ovarian disease nature.Besides,the diagnosis accuracy can be increased by combined examination.