外周血白细胞与妊娠期糖尿病的关系探讨

Relationship between Peripheral Leukocyte and Gestational Diabetes Mellitus

目的探讨外周血白细胞浓度与妊娠期糖尿病(GDM)的相关性。方法选取2014年1月至12月江苏省南通市妇幼保健院产科门诊以及住院的220例产妇为研究对象。从孕产妇健康手册、医疗档案和实验室信息管理系统中获取孕妇的相关信息(如年龄、孕周以及其前20周白细胞参数值等),比较106位GDM患者和114位正常葡萄糖耐量孕妇的妊娠期前20周外周血白细胞浓度。结果发与正常组相比,GDM患者妊娠期前20周白细胞总数及中性粒细胞数明显更高(P<0.05)。结论妊娠期前20周白细胞计数的变化与GDM优贯,白细胞浓度可作为一种GDM发生潜在的预测指标,在孕前即可筛选出GDM高危孕妇,在孕前及孕期及早干预以降低GDM对母婴的不利影响。

Objective To investigate the relationship between peripheral blood leukocyte concentration and gestational diabetes mellitus(GDM).Methods Totally 220 puerperae admitted to the Obstetrics Clinic and Inpatient of Nantong Maternal and Child Health Hospital from January to December 2014 were slected.The relevant information of pregnant women(such as age,gestational age and leukocyte parameters in the first 20 weeks,etc.)was obtained from maternal health manual,medical file and laboratory information management system.The leukocyte concentration of peripheral blood of 106 patients with GDM and 114 patients with normal glucose tolerance in the first 20 weeks of pregnancy were compared.Results There was a significant increase in the number of white blood cells and the number of neutrophils in the GDM group compared with the normal group in the first 20 weeks of pregnancy(P<0.05).Conclusion The change of the white blood cell count in the first 20 weeks of pregnancy is related to GDM,and the white blood cell concentration can be used as a potential predictor of GDM.Pregnant women with high risk of GDM can be screened out before pregnancy and early intervention before pregnancy and during pregnancy should be performed to reduce the adverse impact of GDM on mothers and infants.